摘要
目的:探讨鼻、喉部神经内分泌癌的临床病理特点、治疗方法及疗效。方法:回顾性分析6例鼻、喉部神经内分泌癌患者的临床资料。采用单纯放疗1例,以手术为主的综合治疗5例。结果:全部患者随访11～84个月;2例术后复发,2例术后出现颈淋巴结转移,其中1例行颈淋巴结清扫术,1例无手术指征而行放、化疗。3例出现局部复发、颈部淋巴结肿大、肝或肺转移。至末次随访,4例死亡,2例无瘤生存。结论:鼻、喉部神经内分泌癌是一组形态、预后各异的病变,正确诊断有赖于临床特点、电镜、免疫组织化学检查结果。CT及MRI检查有助了解病变的范围及性质。不同病理类型神经内分泌癌的治疗方法及预后不同,宜采用以手术为主的综合治疗。
Objective：To investigate the clinopathological features,therapeutic methods and therapeutic effects of neuroendocrine carcinoma in nasal and laryngeal region. Method： Six cases with neuroendocrine carcinoma of the nose and the larynx were analyzed retrospectively. All cases were proved by pathology and immmunohistochemis- try. One case was treated by only radiotherapy, and five cases by combined treatment（surgery followed by radio- therapy and chemotherapy）. Result^All the patients were followed up for a period of 11-84 months. Two cases showed recurrence after operation. Three cases occurred cervical lymph node metastasis,of which 2 cases received neck dissection and 1 case received chemotherapy and radiotherapy due to no surgical indications. Three cases oc- cured local recurrence, cervical tymphadenopathy, liver or lung metastases. Until the last follow up,four patients died of tumor,while two patients lived with no evidence of disease. Conclusion：Nasal and laryngeal neuroendocrine carcinoma is composed of a group of different morphology and prognosis lesions. Corrent diagnosis depends on clin- ical characteristic, electron microscopic and immunohistochemical examination. CT and MRI examination could be helpful to understand the extent of disease and lesion nature. The prognosis and treatment method of neuroendo- crine carcinoma were vary with different pathological types. Combined treatment based on surgery should be a- dopted to the disease.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2013年第9期451-454,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
鼻
喉
神经内分泌肿瘤
nose
larynx
neuroenclocrine carcinoma
