摘要
目的探讨腭部低分化神经内分泌癌的临床病理特征、诊断及鉴别诊断。方法回顾性分析1例腭部低分化神经内分泌癌患者临床资料、组织形态及免疫表型结果,并复习相关文献。结果患者男性,58岁,主要表现为左侧腭部肿块,光镜观察肿瘤细胞呈弥漫性分布,局灶巢状或片状分布,小至中等大小,圆形或卵圆形,胞质稀少,胞核圆形或卵圆形,深染,核仁不明显,染色质细腻,核分裂象易见。免疫表型示瘤细胞Syn+++、CgA++、CD56++、EMA+++、CKpan+++、CD99++和Ki-67 90%+,CD3、CD20、CD23、CD34、CD43、CD79α、CD138、MPO、LCA、S100、MyoD1、DES、perforin和calponin均-。结论腭部低分化神经内分泌癌是一种罕见的高度恶性肿瘤,缺乏典型的临床表现,诊断和鉴别诊断需结合病理形态和免疫表型。
Objective To study the clinicopathological features,diagnosis and differential diagnosis of poorly differentiated neuroendocrine carcinoma of the palatal.Methods The clinical data,pathological morphology and immunophenotype of a case with poorly differentiated neuroendocrine carcinoma of the palatal were analysed retrospectively,and the related literatures were reviewed.Results A 58-year-old male patient mainly experienced a mass in left palate.Microscopically,the round or oval cells were small to medium-sized with scarce cytoplasm and arranged diffusely with local nest-like or flaky distribution.The hyperchromatic nuclei were round or oval with inconspicuous nucleoli,exquisite chromatin and obvious mitoses.Immunohistochemically,tumor cells were stained positively for CgA,Syn,CD56,EMA,CKpan,CD99,and Ki-67,but negative for CD3,CD20,CD23,CD34,CD43,CD79α,CD138,MPO,LCA,S100,MyoD1,DES,perforin and calponin.Conclusions Poorly differentiated neuroendocrine carcinoma of the palatal is a rare high-grade malignant tumor and lacks characteristic manifestations.Pathological morphology and immune phenotype are very useful for its diagnosis and differential diagnosis.
出处
《齐齐哈尔医学院学报》
2013年第4期510-511,共2页
Journal of Qiqihar Medical University
关键词
腭部
神经内分泌癌
鉴别诊断
免疫表型
Palate
Neuroendocrine carcinoma
Differential diagnosis
Immune phenotype
