摘要
目的分析各年龄阶段儿童血清中免疫球蛋白IgG、IgM、IgA、IgE含量,探讨免疫球蛋白含量与年龄的关系。方法收集该院体检健康儿童1717例,根据年龄分为12个组,用透射比浊法检测血清免疫球蛋白含量,并与对照组(179例)进行比较。结果 IgG在新生儿血清含量高,出生后逐渐降低,3月时降到最低点(平均浓度3.21g/L),之后随年龄增长,逐渐升高,8岁后达到成人水平。新生儿血清IgM、IgA、IgE含量最低,随年龄增长浓度也增加,分别在4、13、8岁后达成人水平。结论儿童与成人血清中免疫球蛋白含量有较大差别,评估儿童免疫功能时不能以成人参考区间为依据,实验室应根据地域、检测方法以及年龄等因素建立自身的参考区间。
Objective To study serum immunoglobulin IgG,IgM,IgA,IgE levels of children and investigate relationship of im- munoglobulin levels and age. Methods 1 717 healthy children were enrolled and divided into 12 groups based on age,serum immu- noglobulin IgG,IgM,IgA, IgE levels were detected by immune turbidimetry and compared with control group（179 healthy adults）. Results IgG level in the neonatal serum was high,decreased with age gradually,and reached the lowest point in the 3 months old （mean concentration was 3.21 g/L）. then gradually increased with age,reached adult levels after 8 years old. IgM,IgA,IgE levels in the neonatal serum is the lowest, then gradually increased with age, reached adult levels after 4,13,8 years old respectively. Conclu- sion Serum immunoglobulin levels in children are different from adults,we shouldn＇t simply use the reference range of adults to e- valuate children immune function, laboratories should establish reference range based on different area,method for detecting immu- noglobulin and age.
出处
《国际检验医学杂志》
CAS
2013年第7期825-826,共2页
International Journal of Laboratory Medicine
关键词
血清
免疫球蛋白类
参考值
serum
immunoglobulins
reference values
