摘要
目的:探讨温州地区儿童血清前白蛋白(PA)、胆碱酯酶(CHE)性别、年龄分布规律,建立本地区儿童PA、CHE生物参考区间。方法:采用回顾性研究,从2016年4月至2017年3月来温州医科大学附属第二医院儿童保健科体检的人群中筛选出3个月~12岁的健康儿童,将其按照性别、年龄分成3个月~3岁(婴幼儿男、女组)、~6岁(学龄前男、女组)、~12岁(学龄男、女组),共6组,剔除离群值,获得合格例数1 441例,进行统计学分析,以P<0.05为差异有统计学意义,对差异无统计学意义(P>0.05)的组别进行合并后取参考区间,差异有统计学意义(P<0.05)的组别不进行合并。结果:PA参考区间为114.9~231.3 mg/L(3个月~3岁),126.4~237.4 mg/L(4岁~6岁),136.7~273.5 mg/L(7岁~12岁)。同年龄组男、女童间差异无统计学意义(P>0.05),但与年龄呈正相关(r=0.459,P<0.01)。CHE参考区间为7 014~14 900 U/L(3个月~6岁),7 079~14 246 U/L(7岁~12岁男),6 709~13 163 U/L(7岁~12岁女),除学龄组外,其余小组男、女童间差异无统计学意义(P>0.05);且与年龄无相关关系(r=0.017,P>0.05)。结论:本研究建立的不同年龄段PA、CHE参考区间,可为临床医师评估儿童营养状态和肝脏合成功能提供参考。
Objective： To establish the biological reference interval of serum prealbumin and cholinesterase for children （infant to school-age children） in Wenzhou. Methods： Retrospective study was adopted. The data of healthy infant （3 months to 12 years old） who visited the Second Affiliated Hospital of Wenzhou Medical University during April 2016 to March 2017 was collected. The qualified persons were divided into 6 groups according to gender and age, namely 3 months-3 years old （male, female infant group）, -6 years old （male, female preschool group）, 12 years old （male, female school-age group）. By eliminating outliers within each group, 1 441 cases get qualified. Statistical methods was applied in comparing PA and CHE levels among the groups, if there was no statistical significance （P〉0.05）, the two age groups were merged, otherwise they won’t be merged. Results： The children’s serum PA reference intervals were 114.9-231.3, 126.4-237.4 and 136.7-273.5 mg/L for 3 months-3 years old, 4-6 years old, 7-12 years old. The difference of serum PA between male and female with the same age groups had no statistical significance （P〉0.05）. PA level was positively correlated with age （r=0.497, P〈0.01）. The children’s serum CHE reference intervals were 7 014-14 900, 7 079-14 246, 6 709-13 163 U/L for 3 months-6 years old, 7-12 years old （male）, 7-12 years old （female）. In addition to the school age group, the difference of serum CHE between male and female with the same age groups had no statistical significance （P〉0.05）. CHE level was not correlated with age （r=0.017, P〉0.05）. Conclusion： According to the research, reference intervals of PA and CHE are established for children at different age groups in the laboratory and reference in assessing children’s nutritional status and liver function are provided for clinicians.
作者
李姗姗
倪莉
朱丽丹
徐晓媛
丁红香
LI Shanshan;NI Li;ZHU Lidan;XU Xiaoyuan;DING Hongxiang(Department of Clinical Labo- ratory, the Second Affiliated Hospital ＆ Yuying Children ＂s Hospital of Wenzhou Medical University, Wenzhou, 32502)
出处
《温州医科大学学报》
CAS
2017年第11期824-827,共4页
Journal of Wenzhou Medical University
关键词
前白蛋白
胆碱酯酶
儿童
参考区间
prealbumin
cholinesterase
child
reference intervals
