摘要
细胞内存在多种不同的Ca2 +信号基本单位 ,这些Ca2 +信号基本单位依赖于刺激浓度的等级体系组织。低水平的刺激激活单通道开放 ,产生Ca2 +脉冲或Ca2 +夸克 ;中等组织水平刺激则产生喷烟和火花 ,似乎与一小簇通道的激活有关 ;高浓度刺激时 ,Ca2 +信号基本单位协同产生球形Ca2 +波。这些Ca2 +基本单位既体现了钙释放单位 (Ca2 +releaseunit)的特征 ,又导致Ca2 +信号传播在时空上的差异性 。
There are many different elementary intracellur calcium signalling in the cell. These events appear to have a hierarchical organization depending on stimulus intensity.Low levels of stimulation activate individual channels such as the blips or quarks;The next level of organization is the puffs and sparks,which appear to be derived from small clusters of channels.At high stimulus intensities these elementary events are coordinated to give global events.These events not only present the character of Ca 2+ release unit, also lead to different complex spatiotemporal organization of calcium signalling, emphasizing the hierachical organization and local control model of calcium signalling.
出处
《生理科学进展》
CAS
CSCD
北大核心
2000年第2期109-114,共6页
Progress in Physiological Sciences
基金
国家自然科学基金!(394 70 32 5)
