摘要
目的:研究USP22和Nanog在结肠癌组织中的表达及其与临床病理因素的关系.方法:采用免疫组织化学法检测USP22和Nanog在80例结肠癌组织,35例结肠腺瘤组织及40例癌旁正常结肠组织中的表达.结果:USP22在结肠癌中的阳性表达率明显高于结肠腺瘤和正常结直肠黏膜组织(P<0.05),但结肠腺瘤和癌旁正常组织的阳性表达率差异无统计学意义(P>0.05),Nanog在癌旁正常组织,结肠腺瘤和结肠腺癌中的阳性表达率差异均有统计学意义(P<0.05).USP22和Nanog的表达与Dukes分期,组织学分级,淋巴结转移以及浸润深度均有关(P<0.05);USP22和Nanog在结肠癌组织中的表达呈正相关(r=0.509,P<0.01).结论:USP22和Nanog的表达与结肠癌的发生发展有关,二者在结肠癌的细胞增殖、浸润和转移中有协同作用.他们有望成为结肠癌的早期诊断指标和治疗靶点.
AIM： To investigate the expression of USP22 and Nanog in colon cancer and to explore their rela- tionship with clinicopathological factors of this malignancy. METHODS： The expression of USP22 and Nanog was detected by immunohistochemistry in 80 cas- es of colonic adenocarcinorna, 35 cases of colonic adenoma and 40 cases of normal colonic tissue. RESULTS： The positive rate of USP22 expres- sion in colonic adenocarcinoma was signifi- cantly higher than those in colonic adenoma and normal tissues （both P 〈 0.05）, but there was no significant difference between colonic adenorna and adenocarcinoma （P 〉 0.05）. The positive rate of Nanog expression differed significantly in normal colonic tissue, colonic adenoma and co- lonic adenocarcinoma （all P 〈 0.05）. The expres- sion of USP22 and Nanog was correlated with Duke＇s stage, histopathological grade, lymphnode metastasis and depth of invasion （all P 〈 0.05）. There was a positive correlation between the expressions of USP22 and that of Nanog in colonic adenocarcinoma （r -- 0.509, P 〈 0.01）. CONCLUSION： The expression of USP22 and Nanog is closely related to the occurrence and development of colonic adenocarcinoma, and they have synergistic effect on infiltration, invasion and metastasis of colonic adenocarci- noma. USP22 and Nanog may be used as early diagnostic markers and therapeutic targets for colorectal adenocarcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第8期719-723,共5页
World Chinese Journal of Digestology
