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Piwil2与肿瘤的关系及研究进展 被引量：3

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摘要 Piwil2属于Argonaute蛋白家族的PIWI亚家族,在人类中目前已发现,Argonaute蛋白家族的两个亚族:一类为类似植物拟南芥Argonaute1的A-GO亚族,主要为AGO1、AGO2、AGO3、AGO44个亚型:另一类为类似果蝇中Piwi的PIWI亚族,主要为Piwil1(HIWI)、Piwil2(HILI)、Piwil 3、Piwil 4(HIWIL2)4个亚型[1]。
作者 肖昆 孙庭
机构地区 南昌大学第一附属医院泌尿外科
出处 《江西医药》 CAS 2013年第3期256-259,共4页 Jiangxi Medical Journal
关键词 Piwil2 肿瘤 癌基因 抑癌基因 细胞凋亡
分类号 R9 [医药卫生—药学]
  • 相关文献

参考文献18

  • 1Gao, J.X,Zhou, Q.Epigenetic progenitors in tumor initiation and development.Drug Discov Today: Dis Model,2009.
  • 2Li L,Yu C,Gao H,et al.Argonaute proteins:potential biomarkersfor human colon cancerBMC Cancer,2010.
  • 3He G,Chen L,Ye Y,Xiao Y,Hua K,Jarjoura D,Nakano T,Barsky S H,Shen R,Gao JX.PIWIL2 expressed in various stages of cervical neoplasia is a otential complementary marker for p16INK4aTranslation Research,2010.
  • 4Yin D T,Wang L,Sun J,et al.Homozygous deletion but not mutation of exons5and8of the fragile histidine triad(FHIT)gene is associated with features of differ-entiated thyroid carcinomaAnnals of Clinical and Laboratory Science,2010.
  • 5Liu J J,Shen R,Chen L,et al.Piwil2 is expressed in variousstages of breast cancers and has the potential to be used as anovel biomarkerInt J Clin Exp Pathol,2010.
  • 6lee JH,Schutte D,Wulf G,et al.Stem cell protein Piwil2is widely ex-pressed in tumors and inhibits apoptosis thigh activation of Stat3/Bcl XL pathwayHuman Molecular Genetics,2006.
  • 7Bartkova J,Horejsi Z,Koed K,et al.DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisNature,2005.
  • 8何向阳,巫巧雄,黄小佳,常新.肾癌的临床诊治探讨[J].江西医药,2006,41(1):5-6. 被引量：4
  • 9Kuramochi-Miyagawa S,Kimura T,Ijiri TW,et a1.amammalianmember of piwi family gene,is essential for spermatogenesisDevelopment,2004.
  • 10Niu GL,Wright KL,Ma YH,et al.Role of Stat3in regulating p53expression and functionMolecular and Cellular Probes,2005.

二级参考文献48

  • 1胡天政.肾癌预后相关因素分析[J].国外医学（泌尿系统分册）,1995,15(4):151-153. 被引量：3
  • 2Yin DT, Wang L, Sun J, et al. Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad ( FHIT ) gene is associated with features of differentiated thyroid carcinoma. Ann Clin Lab Sci,2010,40:267-272.
  • 3Minernatsu T, Suzuki M, Sanno N, et al. PTFG overexpression is correlated with angiogenesis in human pituitary adenomas. J Endocr Pathol, 2006,17 : 143-153.
  • 4Gao JX. Cancer stem cells: the lessons from pre-cancerous stem cells. J Cell Mol Med, 2008,12:67-96.
  • 5Sasaki T, Shiohama A, Minoshima S, et al. Identification of eight members of the Argonaute family in the human genome small star, filled. Genomics .2003,82:323-330.
  • 6widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. Hum Mol Genet,2006, 15 : 201-211.
  • 7Yin DT, Wang L, Sun J, et al. Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma. Int J Clin Exp Pathol, 2010,3:482-491.
  • 8Girard A, Saehidanandam R, Hannon GJ, et al. A germlinespecific class of small RNAs binds mammalian Piwi proteins. Nature, 2006,442 : 199-202.
  • 9Grivna ST, Beyret E, Wang Z, et al. A novel class of small RNAs in mouse spermatogenic ceils. Genes Dev,2006,20 : 1709-1714.
  • 10Aravin A, Gaidatzis D, Pfeffer S, et al. A novel class of small RNAs bind to MILI protein in mouse testis. Nature, 2006,442 : 203 -207.

共引文献15

同被引文献31

引证文献3

二级引证文献11

江西医药
2013年 第3期

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