期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

人附睾蛋白4在临床应用中的研究进展 被引量：4

The progress of human epididymis protein 4 in clinical application
原文传递
导出
摘要 人附睾蛋白4(human epididymis protein 4,HE4)是近年被承认的一个血清肿瘤标志物,因其在众多肿瘤中的高表达,对卵巢癌、子宫内膜癌、肺癌、乳腺癌子宫内膜异位症等疾病的早期诊断和监测复发具有重要价值。本文就HE4在临床应用中的研究进展作一综述。 As a promised serum tumor marker in recent years, HE plays a key role in ovarian cancer, endometrial cancer, lung cancer, breast cancer, endometriosis and other diseases in the early diagnosis and monitoring recurrence because of its high expression in many tumors. Addtionally, the attampt that HE4 may play an inhibit role in the development of tumors could be a novel direction for the therapy of tumors. This review is to analyze the research progress and clinical application of HE4.
作者 张景宇 石琨
机构地区 哈尔滨医科大学附属第二医院妇产科
出处 《中国优生与遗传杂志》 2013年第4期3-4,71,共3页 Chinese Journal of Birth Health & Heredity
关键词 人附睾蛋白4 血清肿瘤标志物 临床应用 疾病诊断 HE4 Serum tumor markers Clinical application Disease diagnosis
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献20

  • 1Kirchhoff C,Habben I, Ivell R, et al. A major human epididymis - specific cDNA encodes a protein with sequence homology to extracel- lular proteinase inhibitors [ J ]. Biol Reprod, 1991,45 ( 2 ) : 350 - 357.
  • 2Clauss A, Lilja H. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey a- cidic protein[J]. Biochem J,2002,368( Pt1) :233 -242.
  • 3Schalkwijk J. The trappin gene family: proteins defined by an N - terminal transglutaminase substrate domain and a C - terminal four - disulphide core [ J ]. Biochem J, 1999,340 ( Pt3 ) : 569 - 577.
  • 4Bingle L, Singleton V, Bingle CD. The putative ovarian tumour mark- er gene HE4 ( WFDC2 ), is expressed in normal tissues and under- goes complex alternative splicing to yield multiple protein isoforms [ J]. Oncogene, 2002,21 ( 17 ) : 2768 - 2773.
  • 5Drapkin R, et al. Human epididymis protein 4 ( HE4 ) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas[ J]. Cancer Res, 2005,65 (6) : 2162 - 2169.
  • 6Galgano MT. Comprehensive analysis of HE4 expression in normal and malignant human tissues [ J ]. Mod Pathol ,2006 ,19 ( 6 ) : 847 - 853.
  • 7Hellstrom I, et al. The HFA (WFDC2) protein is a biomarker for o- varian carcinoma[ J]. Cancer Res ,2003,63 ( 13 ) : 3695 - 3700.
  • 8Diamandis EP. Cancer biomarkers: can we turn recent failures into success? [ J]. J Natl Cancer Inst,2010,102( 19): 1462 - 1467.
  • 9Havrilesky LI, Whitehead CM, Rubatt JM, et al. Evaluation of bio- marker panels for early stage ovarian cancer detection and monitoring for disease recurrence [ J ]. Gynecol Oncol,2008,110 ( 3 ) : 374 - 382.
  • 10Gao L, Cheng HY, Dong L, et al. The role of HFA in ovarian canc- er: inhibiting tumour cell proliferation and metastasis[J]. J Int Med Res ,2011,39 ( 5 ) : 1645 - 1660.

二级参考文献33

  • 1Kirchhoff C, Habben I, Ivell R, et al. A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors, 1991, 45 : 350- 357.
  • 2Wang K, Gan L, Jeffery E, et al. Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray. Gene, 1999, 229 : 101-108.
  • 3Drapkin R, yon Homten HH, Lin Y, et al . Human epididymis protein 4 (HFA) is a secreted glycoprotcin that isoverexpressed by serous and endometrioid ovarian carcinomas. Cancer Res, 2005, 65:2162-2169.
  • 4Hellstrom I, Raycraft J, Hayden-Ledbetter M, et al. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res,2003, 63:3695-3700.
  • 5Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol,2008,108: 402-408.
  • 6Galgano MT, Hampton GM, Frierson HF Jr. Comprehensive analysis of HE4 expression in normal and malignant human tissues. Modem Path,2006, 19:847-853.
  • 7Bingle L, Singleton V, Bingle CD. The putative ovarian tumour marker gene HE4 (WFDC2) is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. Oncogene, 2002, 21: 2768-2773.
  • 8Kirchhoff C,Habben I,Ivell R,et al.A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors[J].Biol Reprod,1991,45(2):350-357.
  • 9Montagnana M,Lippi G,Ruzzenente O,et al.The utility of serum human epididymis protein 4(HE4) in patients with a pelvic mass[J].J Clin Lab Anal,2009,23(5):331-335.
  • 10Hellstrom I,Heagerty PJ,Swisher EM,et al.Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms[J].Cancer Lett,2010,296(1):43-48.

共引文献72

同被引文献34

  • 1杭建峰,吴英松,余伟鸿,徐伟文,王从容,裘宇容,李明.人甲胎蛋白时间分辨免疫荧光分析试剂盒的研制[J].第一军医大学学报,2005,25(3):313-317. 被引量：9
  • 2杭建峰,吴英松,徐伟文,周志聪,李明.CA125时间分辨荧光免疫分析试剂盒的研制[J].热带医学杂志,2005,5(5):567-570. 被引量：8
  • 3杭建峰,吴英松,余伟鸿,黄颖,李明.癌胚抗原的时间分辨免疫荧光分析及其诊断试剂的研制[J].细胞与分子免疫学杂志,2006,22(1):121-124. 被引量：28
  • 4武学成,何林,周克元.时间分辨荧光免疫分析技术及临床应用[J].医学综述,2006,12(7):434-436. 被引量：32
  • 5Jemal A, Tiwari RC, Murray T, et al.Cancer statistics, 2004 [J]. CA Cancer J Clin, 2004,54( 1 ) : 8-29.
  • 6Stewart BW, WHO, Kleihues P.World cancer report [ M ].Lyon (France) : IARC Press, 2003.
  • 7Edgell T, Martin-Roussety G, Barker G, et al.Phase Ⅱ biomarker trial of a muhimarker diagnostic for ovarian cancer[J].J Cancer Res Clin Oncol,2010, 136(7) : 1079-1088.
  • 8Bingle L,Singleton V,Bingle CD.The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms [J ] .Oncogene, 2002,21 ( 17 ) : 2768-2773.
  • 9Andersen MR,Goff BA,Lowe KA,et al.Use of a Symptom Index,CA125,and HE 4 to predict ovarian cancer[J].Gynecol Oncol, 2010,116(3) :378-383.
  • 10Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian cancer in patients with a pelvic mass [ J ]. Gynecol Oncol, 2008,108 (2) : 402-408.

引证文献4

二级引证文献21

中国优生与遗传杂志
2013年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部