摘要
目的探讨生存素在胰腺癌组织中的表达及其临床意义。方法应用免疫组化EliVisionTMPlus法检测70例手术切除的原发性胰腺癌组织及15例癌旁非肿瘤胰腺组织中生存素的表达。结果生存素在70例原发性胰腺癌组织中的阳性率为70.0%(49/70),而在癌旁非肿瘤胰腺组织中未见表达;生存素表达与性别、年龄及肿瘤部位无关,与肿瘤大小、分化程度、TNM分期、淋巴结转移、生存期显著相关(P<0.05)。结论生存素的表达与胰腺癌的临床病理指标密切相关,其高表达提示患者预后不良。
Objective To investigate the expression and clinical significance of survivin in pancreatic carcinoma.Methods The expression of survivin was detected in 70 pieces of primary pancreatic carcinoma tissue and 15 pieces of nontumorous pancreatic tissue by EliVisionTM Plus immunohistochemistry method.Results The positive rate of survivin in 70 pieces of primary pancreatic carcinoma tissue was 70.0%（49 /70）,and there was no expression of survivin in adjacent nontumorous pancreatic tissues;the expression of survivin did not correlate with gender,age and the tumor position,while it was significantly correlated with the tumor size,differentiation grade,TNM stages,lymph node metastasis and survival（P 0.05）.Conclusion The survivin expression is closely related with clinicopathological parameters of patients with pancreatic cancer.The over-expression survivin may get poor prognostic predictors.
出处
《解放军医药杂志》
CAS
2013年第3期47-49,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
胰腺肿瘤
生存素
免疫组织化学
预后
Pancreatic neoplasm
Survivin
Immunohistochemistry
Prognosis
