摘要
目的研究生存素(Survivin)蛋白在非小细胞肺癌(NSCLC)组织中的表达及其与淋巴结转移和预后的关系。方法用免疫组化方法检测82例NSCLC组织中生存素的表达,分析其与年龄、性别、癌的组织学类型、组织分化程度、淋巴结转移、临床复发和手术后生存期长短的关系。结果82例NSCLC组织中生存素阳性率为52%。生存素表达与淋巴结转移呈正相关(P=0.001,r=0.237),与患者三年生存率呈负相关(P=0.019,r=-0.265)。生存素表达与年龄、性别、癌组织学类型、组织分化程度和临床分期均无关(P>0.05)。结论生存素蛋白的表达与NSCLC的淋巴结转移和预后密切相关,其高表达提示非小细胞肺癌患者预后不良。
Objective To investigate the relationship of expression of survivin with lymphoid metastasis and prognosis in patients with non small cell lung carcinoma （ NSCLC）. Methods Immunohistochemical staining was used to detect the expression of survivin protein in 82 cases of NSCLC. The relationship between the expression of survivin and age, sex, histological type, differentiation, lymphoid metastasis, clinical stage, and survival time of the patients was analyzed. Results The total expressive rate of survivin in 82 cases of NSCLC was 52% . And the expression of survivin protein was associated positively with lymphoid metastasis of NSCLC （ P = 0.001 ,r = 0.237）. The expression of survivin was associated negatively with the three - year surviving rate of NSCLC （ P = 0.019, r = - 0. 265）. No relationship of the expression of survivin with the age, sex, histological type, differentiation, and clinical stage was observed （ P 〉 0.05 ）. Conclusion The expression of survivin protein is closely associated with the lymphoid metastasis and prognosis NSCLC, its high expression suggests probable lymphoid nodular metastasis and poor prognosis.
出处
《中国热带医学》
CAS
2006年第8期1373-1374,共2页
China Tropical Medicine
基金
广东省重点攻关项目(编号:2005B30601001)
关键词
肺肿瘤
免疫组织化学
生存素
淋巴转移
预后
Lung cancer
Immunohistochemistry
Survivin
Lymphoid metastasis
Prognosis
