摘要
目的 对植入式颈动脉压迫训练的效果进行研究。方法 将实验犬分为 3组 ,低血压状态下直接结扎组 6只 ,低血压状态下训练结扎组 6只 ,对照组 3只 ,前两组均降低血压 30～ 40mmHg ,将其颈总动脉暴露 ,训练组在电磁流量计监视下 ,利用颈动脉阻断夹每隔 8小时阻断其血流的 2 0 % ,直至全部阻断 ,结扎组经过相同的处理时间后 ,直接结扎其颈总动脉 ,每组动物在实验前及处死前做SPECT检查。SPECT值以中间层及其上下两层的右/左值取均值。结果 SPECT值 ,在α=0 .0 1时 ,训练组比结扎组有显著提高 ,两者皆与正常值有显著差异。组织学改变为结扎组 2只双侧、其余同侧出现了严重的脑缺血改变 ,训练组有 1只双侧、1只单侧出现了轻微的脑缺血改变。结论 植入式颈动脉压迫训练的方法可以明显提高单侧颈动脉阻断后脑对缺血的耐受能力 ,为临床上进行颈动脉外科手术提供了一个可行的思路。
Objective To evaluate the effect of the implantable CA occluded training method.Methods 15 dogs were devided into hypotension with directly right CA ligation group (HDL) and hypertension with implantable CA occluded training (HIT) group.Each had 6 dogs.The remaining dogs served as control group.After inducing hypertension (30～40mmHg mean blood pressure),the CCA blood flow of the HIT dogs were gradually reduced 20% for every 8 hours by CA occluded clip,untill it was utterly occluded.HDL group dogs were ligated,following the same procedure time with hypotension.All dogs were examined by SPECT after inducing hypertension and before they were killed.The brain tissues of all dogs endured the same way descried priviously.Results SPECT:HIT group value remarkably improved when contrasted with HDL group and both two groups were distinctively different in values that were obtained first time in this part,with statistic significance.Histological change in HDL group was the same as described in part one.The HIT group was found slightly ischemic change in cerebral cortex of 1 dog in ipsilateral side and 1 dog bilateral side.Conclusion Implantabal CA occluded training can remakably improve the ability of torlerance to cerebral ischemia produced by unilateral CCA occluding.Thus it provides practical method to treat tumors in head and neck in clinic practice.SPECT examination can objectively reflect the cerebral blood flow and forming of tributary circulation of brains both sides.
出处
《现代口腔医学杂志》
CAS
CSCD
2000年第5期306-308,共3页
Journal of Modern Stomatology
基金
陕西省自然科学基金资助课题!(编号:39338)
关键词
颈动脉压迫训练
SPECT
脑缺血
实验研究
Implantable carotid artery occluded training SPECT Cerebral ischemia
