摘要
目的 :探讨 C反应蛋白 (CRP)对冠心病患者冠状动脉 (冠脉 )介入治疗术中并发症及术后住院期间严重冠脉事件发生的预测价值。 方法 :对 70例住院接受经皮冠状动脉腔内成形术 (PTCA)及冠脉内支架置入术 (CS)的冠心病患者术前测定血清CRP水平。按 CRP水平将患者分为 2组 :即 A组 (CRP水平 <3mg/ L ,n=40 )及 B组 (CRP水平≥ 3mg/ L ,n=30 )。分析并记录每例患者术中冠脉夹层及血栓形成等的发生情况 ,并观察住院期间是否发生严重冠脉事件。 结果 :B组患者 PTCA及 CS术中血栓形成的发生率显著高于 A组 (分别为 36 .7%对 12 .5 % ,P=0 .0 17及 30 .0 %对 2 .5 % ,P=0 .0 0 1)。B组 PTCA术中斑块夹层的发生率显著大于 A组 (86 .7%对 6 0 .0 % ,P=0 .0 1)。B组患者介入治疗术中冠脉痉挛的发生率显著大于 A组 (P=0 .0 4)。住院期间 2组患者均无严重冠脉事件发生。 结论 :术前血清 CRP水平对 PTCA及 CS术中并发症的发生具有较强的预测价值 ,提示冠脉介入治疗术中并发症的发生与病变的炎症反应增强有关。
Objective:The aim of this study was to investigate whether intraprocedural and in hospital complications after percutaneous transluminal coronary angioplasty (PTCA) and stenting (CS) could be predicted by baseline levels of C reactive protein (CRP). Methods:Preprocedural serum levels of CRP were measured in 70 cases undergoing coronary interventions.According to the level of CRP,the patients were divided into two groups:group A (CRP<3 mg/L,n=40) and group B (CRP≥3 mg/L,n=30).Intraprocedural plaque dissection,thrombosis (threatened or occluded),coronary spasm and in hospital major adverse coronary events (MACE) were carefully observed and recorded. Results:The incidences of intraprocedural thrombosis after PTCA and CS were higher in group B compared with those in group A (36 7% vs 12 5%,P=0 017,and 30 0% vs 2 5%,P=0 001,respectively).The percentage of plaque dissection after PTCA in group B was higher than that in group A (86 7% vs 60 0%,P=0 01).The rate of intraprocedural coronary spasm was also higher in group B compared with group A (10% vs 0%,P=0 04).In hospital MACE was not occurred in both groups. Conclusions:Preprocedural CRP level is a powerful predictor of intraprocedural complications,suggesting that intraprocedural complications are significantly influenced by the baseline degree of inflammatory activation.
出处
《中国循环杂志》
CSCD
北大核心
2000年第5期264-265,共2页
Chinese Circulation Journal
关键词
冠心病
介入治疗
C反应蛋白
并发症
预测
PTCA
C-reactive protein
Percutaneous transluminal coronary angioplasty
Coronary heart disease
