摘要
目的:动态研究川崎病(KD)患儿血清中C-反应蛋白(C-reactive protein,CRP)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在小儿川崎病血管损伤中的作用机制,寻找其与冠状动脉(简称冠脉)损伤之间直接关系的依据。方法:应用酶联免疫吸附实验(ELISA)和免疫乳胶比浊法检测47例川崎病患儿、19例发热疾病患儿(对照组)血清中的CRP和VEGF水平,并将KD患儿分为急性期、亚急性期、恢复期;有冠脉损伤(CAL)组和无冠脉损伤(NCAL)组。结果:KD患儿急性期、亚急性期和恢复期的CRP、VEGF水平均高于发热组,两组间差异有统计学意义(P<0.01);CAL组CRP、VEGF水平明显高于NCAL,差异有统计学意义(P<0.01)。CRP的高峰期在急性期,VEGF的高峰期在亚急性期。结论:CRP和VEGF水平在KD患儿组急性期和亚急性期升高,可能在川崎病患儿血管损伤的病理生理发生机制中发挥重要作用。CRP和VEGF具有预示KD患儿CAL潜在的可能性。
Objective： To dynamically research the mechanism of serum C - reactive protein and vascular endothelial growth factor in children with Kawasaki disease, and find the relationship between C - reactive protein, vascular endothelial growth factor and coronary ar- tery lesion. Methods： The serum levels of C - reactive protein and vascular endothelial growth factor in 47 patients with Kawasaki disease and 19 patients with febrile disease （control group） were detected by double antibody sandwich enzyme linked immunosorbent assay （ELISA） and immunonephelometry, respectively. The patients with Kawasaki disease were divided into acute phase group, subacute phase group, and recovery phase group, as wells as coronary artery lesion group and non - coronary artery lesion group. Results ： The serum tewds of C - reactive protein and vascular endothelial growth factor in children with Kawasaki disease in acute phase group, subacute phase group, and recovery phase group were statistically significantly higher than those in control group （P 〈 0. 01 ） . The serum levels of C - reactive pro- tein and vascular endothelial growth factor in coronary artery lesion group were statistically significantly higher than those in non - coronary artery lesion group （ P 〈 0.01 ） . The peak level of C - reactive protein appeared in the acute phase. The peak level of vascular endothelial growth factor appeared in the subacute phase. Conclusion ： The increases of plasma C - reactive protein and vascular endothelial growth fac- tor levels in acute phase and subacute phase of Kawasaki disease might play important roles in pathophysiology of endothelial damage. Those may potentially be predictors of coronary artery lesion in patients with Kawasaki disease.
出处
《中国妇幼保健》
CAS
北大核心
2013年第9期1432-1434,共3页
Maternal and Child Health Care of China
关键词
川崎病
C-反应蛋白
血管内皮生长因子
儿童
Kawasaki disease
C - reactive protein
Vascular endothelial growth factor
Child
