摘要
目的探讨血清C-反应蛋白(CRP)和免疫球蛋白(IgG、IgA、IgM)的变化与川崎病患者冠状动脉损伤的关系。方法对60例川崎病患儿在急性期进行血清CRP和IgG、IgA、IgM检测,并通过心脏彩色多谱勒超声检查明确患儿冠状动脉损伤情况。结果川崎病患儿在急性期血清CRP和IgG、IgA、IgM水平均显著高于对照组(P<0.01),恢复期上述指标基本恢复到正常水平。伴有冠状动脉损伤的川崎病患儿血清CRP、IgG、IgM水平明显高于无冠状动脉病变的患儿(P<0.01)。结论川崎病患儿血清CRP、IgG、IgM的升高与患儿急性炎症反应程度密切相关,可作为预测川崎病冠状动脉病变的重要参考指标。
【Objective】To explore the correlation of serums C-reaction protein（CRP） and immunoglobulin with coronary artery lesions in children with Kawasaki disease.【Methods】The levels of serum CRP,immunoglobulin（IgG,IgA and IgM） were detected in 60 children with Kawasaki disease before and after treatment.The coronary artery was checked by Doppler echocardiography in these cases.【Results】In acute phase,the levels of serum CRP,IgG,IgA and IgM in patients with Kawasaki disease were significantly higher than those of normal children（P 0.05）.After treatment,the levels of serum CRP,IgG and IgM in patients with Kawasaki disease returned to normal.The levels of serum CRP,IgG and IgM were significantly higher in patients with coronary artery lesions than in those without（P 0.05）.【Conclusion】The levels of CRP,IgG and IgM may be closely associated with the degree of inflammation reaction and these indexes can be taken as the indicators for diagnosis of coronary artery lesions in children with Kawasaki disease.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第6期876-878,共3页
China Journal of Modern Medicine
关键词
川崎病
C反应蛋白
免疫球蛋白
冠状动脉
Kawasaki disease
C-reaction protein
immunoglobulin
coronary artery
