摘要
目的了解医院感染革兰阳性球菌分布构成及耐药性,为临床合理用药提供依据。方法按临床检验操作规程对2009-2011年医院感染革兰阳性球菌进行菌种鉴定和药敏试验。结果分离出革兰阳性球菌1741株,其中金黄色葡萄球菌、凝固酶阴性葡萄球菌和肠球菌属分别占42.96%、31.59%、23.21%;67.51%金黄色葡萄球菌和48.00%凝固酶阴性葡萄球菌来源于下呼吸道,72.03%肠球菌属来源于尿道;金黄色葡萄球菌和凝固酶阴性葡萄球菌对克林霉素、青霉素等呈高耐药性,对替考拉宁耐药率低,对万古霉素、利奈唑胺100.0%敏感;肠球菌属对青霉素、庆大霉素等呈高耐药性,而对利奈唑胺100.0%敏感。结论金黄色葡萄球菌、凝固酶阴性葡萄球菌和肠球菌属居革兰阳性球菌感染前3位,耐药率高且与临床选择有关,对指导临床用药有重要意义。
OBJECTIVE To understand the distribution and drug resistance of the gram-positive cocci causing nosocomiai infections so as to provide basis for the reasonable use of antibiotics. METHODS The bacterial identification and drug susceptibility testing of the gram-positive cocci causing nosocomiaI infections during 2009-- 2011 were performed according to the clinical laboratory procedures. RESULTS Of totally 1741 strains of gram- positive/cocci isolated, Staphylococcus aureus, coagulase-negative Staphylococcus （CNS）, and Enterococci accounted for 42.96%, 31. 59%, and 23.21%,respectively. 67. 5% of the S. aureus strains and 48.0% of the CNS strains were isolated from the lower respiratory tract specimens, 72.0% of Enterococci strains were isolated from the urinary tract specimens. S. aureus and the CNS were highly resistant to gentamycin and penicillin, the drug resistance rate to teicoplanin was low, and the drug susceptibility rates to vancomycin and linezolid were 100.0% ; Enterocci strains were highly resistant to penicillin and gentamycin, and the drug susceptibility rate to linezolid was 100. 0%. CONCLUSION S. aureus, CNS, and Enterococci rank the first three places of the grampositive cocci, the high drug resistance rate is related to the clinical selection, which has great significance in the guidance of clinical medication.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第6期1425-1427,共3页
Chinese Journal of Nosocomiology
关键词
金黄色葡萄球菌
凝固酶阴性葡萄球菌
肠球菌属
耐药性
Staphylococcus aureus
Coagulase-negative Staphylococcus
Enterococcus
Drug resistance
