摘要
目的探讨血浆脑钠素（BNP）浓度与急性心肌梗死（AMI）预后的关系。方法选取55例急性心肌梗死患者为试验组，20名健康者为对照组，统计住院期间及平均12个月随访中患者的年龄、BNP、高敏C反应蛋白、血常规等及心血管事件的发生率，观察心血管事件发生组与未发生组患者血浆BNP浓度差异。结果与对照组相比，AMI患者血浆BNP浓度显著升高，发生心血管事件的患者血浆BNP浓度明显高于未发生者。在控制其他因素后，多因素分析显示BNP是心血管事件发生的独立危险因素。结论AMI急性期血浆BNP浓度显著升高，提示心血管事件发生率高。BNP可作为AMI后心血管事件的预测因子。
Objective To evaluate the value of brain natriuretic peptide （BNP） in estimating risk stratification in patients with acute myocardial infarction （AMI） and to determine the relationship between BNP and adverse cardiac events after AM]. Methods 75 patients were selected into the study, including 55 patients and 20 healthy subjects. The plasma concentrations of BNP, WBC, hs-CRP, the rate of cardiovascular events were stud- ied. The relationship between risk factors and adverse cardiac events was anaylzed. Patients were followed up at 12 months. Results Plasma BNP concentrations in patients with AMI were much higher than those in the health control people. The the clinical endpoints （death/CHF/shock） occurred more frequently in patients with a higher BNP. Plasma BNP concentrations remained independently associated with the clinical end points in muhivariable model that adjusted for potential confounding variables. Conclusion The results of the present study confirm that the elevated BNP concentration is related to the risk stratification and prognosis in patients with AMI. Elevation in BNP concentration are associated with a higher incidence of new CHF and adverse clinical outcomes after AMI. It could serve as a strong predictor for the subsequent development of poor outcomes in AMI patients.
出处
《中国心血管病研究》
CAS
2013年第2期107-110,共4页
Chinese Journal of Cardiovascular Research
关键词
心肌梗死
脑钠素
预后
Acute myocardial infarction
Brain natriuretic peptide
Prognosis
