摘要
目的探讨慢性充血性心力衰竭（CHF）患者血浆B型脑钠肽（BNP）及NT-proBNP改变及其临床意义。方法对该院明确诊断为CHF的120例不同病因、不同心功能分级的慢性充血性心衰患者及50例对照组，测定人院时血浆NT—proBNP及LVEDD、LVESD、LVEF变化，并进行治疗前后对比观察。结果CHF组总体血浆NT-proBNP水平明显高于对照组（P〈0．05），NYHAI级心功能时血浆BNP明显高于对照组（P〈0．05），且Ⅰ、Ⅱ、Ⅲ、Ⅳ级组间血浆BNP依次递增（P〈0．05）。CHF在治疗后明显低于治疗前（P〈0．05）。结论血浆NT-proBNP的水平对CHF的诊断、严重程度和预后评价有重要价值。
Objective To evaluate the clinical significance of the changes of plasma B-type natriuretic paptid and NT-pro BNP levels in patients with chronic heart failure（CHF）. Methods 120 consecutive patients hospitalized for CHF were retrospectively studied. NT-pro BNP and LVEDD,LVESD,LVEF were measured and compared in 120 patients and 50 normal control subjects before medical treatment and on discharge. Results The plasma NT-pro BNP levels in patients with CHF were significantly higher than controls（ P 〈0.05）. The plasma NT-pro BNP levels in patients with cardiac function NYHA [ were significantly higher than controls （ P 〈 0.05 ）. As the cardiac function deteriorated from NYNA [ to NYNA IV, the NT-pro BNP levels increased consecutively with significant differences from each other（ P 〈 0.05）. The plasma NT-pro BNP levels was low when CHF was cured （ P 〈 0. 05 ）. Conclusion Determination of plasma NT-pro BNP levels in patients with CHF were helpful to study the severity and prognosis of disease.
出处
《中国基层医药》
CAS
2011年第8期1038-1040,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
BNP
NT—Pro
BNP
慢性充血性心衰
B-type natriuretic paptid（BNP）
NT-Pro BNP
Chronic heart failure （CHF）
