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HIF-1α的表达与宫颈癌的关系探讨 被引量：3

Investigation of the Relationship between HIF-1α and cervical cancer
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摘要 目的探讨宫颈癌组织中HIF-1α的表达与宫颈癌之间的关系。方法采用免疫组化法检测177例分期为pT1b的宫颈癌患者宫颈组织(观察组)及100例正常宫颈组织(对照组)中HIF-1α的表达。结果宫颈癌患者宫颈组织中HIF-1α的阳性率表达高达79.7%,对照组宫颈组织中HIF-1α的阳性率表达为0%。提示HIF-1α可作为宫颈癌早期筛查和诊断的一个重要参考标准。结论在宫颈癌早期存在着HIF-1α的高表达,因此HIF-1α可作为宫颈癌早期筛查和诊断的一个重要参考标准。 Objective To study the relationship between the expression of HIF-lαin cervical cancer tissue and cervical cancer. Methods The expression of HIF-lα in 177 cases of cervical cancer patients for pTlb cervical tissue （the observation group） and 100 with normal cervical tissue （control group） were detected with immunohistochemical method. Results The expression of HIF-lα of cervical cancer was 79.70//00 and the control group was 00/60. Conclusion HIF-lα can be used as cervical cancer screening and early diagnosis of an important reference standard.
作者 张静
机构地区 延安大学医学院
出处 《西部医学》 2013年第3期341-342,345,共3页 Medical Journal of West China
基金 陕西省科学技术研究发展计划项目(2011K13-02-06) 陕西省教育厅专项科研计划项目(2010JK911) 陕西省卫生厅卫生科研基金项目(2010H24) 延安市科技发展计划项目(2009KS-14) 延安大学自然科学专项科研基金项目(YD2010-06 YD2011-05)
关键词 宫颈癌组织 HIF-1Α 免疫组化法 高表达 Cervical cancer organizations HIF-lα Immunohistochemical method
分类号 R737.33 [医药卫生—肿瘤]
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参考文献10

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共引文献52

同被引文献70

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引证文献3

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西部医学
2013年 第3期

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