摘要
目的:探讨Fhit、Survivin在正常宫颈组织、宫颈上皮内瘤样变(CIN)和宫颈鳞癌中的表达及其临床意义。方法:应用免疫组化S-P法检测Fhit,Survivin的表达情况。结果:从正常宫颈组织-CIN-宫颈鳞癌中,Fhit失表达率和Survivin表达均递增,且有统计学差异(P<0.05)。Fhit失表达与宫颈癌患者的年龄、临床分期、肿瘤大小、肿瘤病理学分级和淋巴结转移均无明显相关(P>0.05)。Survivin表达与宫颈鳞癌病理分级,临床分期及淋巴结转移相关(P<0.05)。宫颈鳞癌中Fhit的失表达和Survivin的表达呈正相关。结论:Fhit失表达发生在CIN期,可为宫颈癌早期诊断方法之一。Survivin则参与了宫颈癌发生、侵袭和转移的过程。Fhit与Survivn的表达异常可能在宫颈癌的发生中起协同作用。
Objective ：To study the expression and significance of Fhit and survivin in cervical intraepithelial neoplasia （CIN） and cervical squamous cell carcinoma （CSCC）. Methods： S -P immunohistochemical method was used in this study. Results： With the development of CIN, Fhit aberrant expression and positive expression of survivin were increased with significant difference. （ P 〈 0. 05 ）. None of the clinical pathologic parameters showed a correlation with Fhit expression. Expression of survivin in CSCC had significant correlations with tumor differention （P 〈 0. 05 ）, clinical stage （P 〈 0. 05 ） and lymphatic metastasis （P 〈 0. 05 ）. Correlation was also found between Fhit aberrant expression and survivin expression in CSCC. Conclusion： Fhit aberrant expression occurred in CIN and it can be used as a mark in the detection of CSCC in an earlier stage. Survivin is correlated with tumorigenesis, invasion, and metastasis, Fhit and survivin may play important roles in the occurrence and development of CSCC.
出处
《现代肿瘤医学》
CAS
2008年第2期265-267,共3页
Journal of Modern Oncology
