摘要
目的了解系统性红斑狼疮(systemic lupus erythematosus,SLE)患者外周血T淋巴细胞的变化,探讨T淋巴细胞与SLE的疾病活动度及24小时尿蛋白的关系。方法采用流式细胞仪对76例SLE患者(低度活动组与高度活动组)及同期36例健康女性(健康对照组)的外周血淋巴细胞亚群进行检测。结果与健康女性比较,75.0%的SLE患者存在淋巴细胞亚群的异常,表现为CD3+CD4+细胞减低(P<0.01),CD3+CD8+细胞增高(P<0.01),CD3+CD4+/CD3+CD8+比值减低,CD3+CD4+/CD3+CD8+比值减低中59.6%出现倒置(P<0.01);T细胞亚群的异常与狼疮活动度、24小时尿蛋白、血沉、补体C3、C4有明显相关性(P<0.05)。结论 T细胞亚群检测不但能提示SLE患者细胞免疫功能受损,还是对SLE疾病活动及严重程度进行判断的参考指标。
Objective To examine the changes of peripheral blood T lymphocyte subsets in the patients with systemic lupus erythematosus （SLE） , and to investigate the relationships between T lymphocyte, disease activity and 24-hour urine protein excretion. Methods Peripheral blood T lymphocyte subsets of 76 patients with systemic lupus erythematosus （SLE） and 36 healthy women were determined by flow eytometry. Results Compared with healthy women, there were abnormalities of peripheral blood T lymphocyte sub- sets in 75.0% of SLE patients. The CD3^＋CD8^＋ cells were lower（P 〈 0.01 ） ,and the CD3＋CD8＋ cells were higher（P 〈 0.01 ）. The ra- tios of CD3^＋CD4^＋ eeIls/CD3^＋CD8^＋ ceils were lower,59.6% of which were inverted （P 〈 0.01 ）. The abnormal T cell subsets signifi- cantly correlated to the disease activity,24-hour urine protein excretion, erythroeyte sedimentation rate and complements C3, C4 in SLE patients. Conclusions Abnormal T cell subsets may suggest that cellular immune functions are impaired in SLE patients, and the ab- normality of T cell subsets is a helpful parameter for lupus activity and severity.
出处
《实用医院临床杂志》
2013年第2期88-90,共3页
Practical Journal of Clinical Medicine
关键词
系统性红斑狼疮
T淋巴细胞亚群
SLEDAI评分
24小时尿蛋白
血沉
补体
Systemic lupus erythematosus
T lymhoeyte subsets
SLEDAI score
24-hour urine protein excretion
Erythrocyte sedimentation rate
Complement
