摘要
目的:探讨五黄糖康灵对2型糖尿病(T2DM)患者血清肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、高敏C-反应蛋白(hs-CRP)的影响。方法:将100例临床确诊的T2DM患者随机分为对照组与观察组各50例。对照组吡格列酮15 mg.d-1早餐前1次服用,胰岛素根据血糖水平不同采用不同的剂量;观察组用五黄糖康灵煎剂每日1剂,2组均8周为一疗程。治疗前后检测血清TNF-α,IL-6,hs-CRP水平,同时检测空腹血糖(FpG)、餐后2 h血糖(2hpG),另设50例门诊健康体检者为健康组作对照。结果:治疗前外周血细胞因子及FpG,2hPG水平与健康组比较明显升高(P<0.01),观察组治疗前后比差异有显著性(P<0.01);治疗后与对照组比,差异有显著性(P<0.01)。结论:五黄糖康灵能降低T2DM患者血清TNF-α,IL-6,CRP及FpG,2hPG水平,具有降低血糖、抗炎症及改善胰岛素抵抗(IR)作用。检测上述细胞因子水平,可用于判定以及治疗T2DM观察的指标及治疗效果。
Objective： To investigate the effects of Wuhuang Tangkangling on tumor necrosis factor-α（TNF-α）, interleukin-6 （ IL-6 ） and high-sensitivity C-reactive protein （hs-CRP） in serum of patients with type 2 diabetes mellitus （ T2DM ）. Method ： One hundred cases of type 2 diabetes mellitus patients were randomly divided into two groups. The control group was treated with pioglita- zone （ 15 mg· d - 1 ） orally once a day in the morning, combined with insulin subcutaneous injection based on blood glucose level. The treatment group was treated with decoction of Wuhuang Tangkang Ling daily, 8 weeks as a course. TNF-α, IL-6, hs-CRP, fasting blood glucose （FBG） and postprandial blood glucose （PBG） were tested for two groups of patients before and after the treatment. And other 50 healthy cases were tested for comparison. Result ： Before treatment, the level of cytokine, FBG and PBG in the serum of patients with T2DM were significantly higher than healthy cases （P 〈 0. 01 ）. In treatment group, difference between before and after the treatment had statistical significance （P 〈 0. 01 ） ; after treatment, difference between treatment group and control group had statistical significance （P 〈 0. 01 ）. Conclusion：Wuhuang Tangkangling could significantly decrease the level of TNF-α, IL-6, hs-CRP, FBG and PBG in patients with T2DM, and could decrease blood glucose, anti inflammatory, and improve insulin resistance. According to testing these cytokines, a new criteria for evaluating the progress of T2DM and the treatment may be approached.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第4期622-624,共3页
China Journal of Chinese Materia Medica
