摘要
目的 探讨痢疾杆菌L型的致病作用。方法 将痢疾杆菌诱导为稳定L型 ,用灌胃法感染C57BL/ 6小鼠 ,观察小鼠的发病情况 ,并对死亡小鼠行细菌L型分离及组织学检查。本试验共分三组 :A组原菌组 ,B组L型组 ,C组生理盐水组。结果 A、B两组对小鼠均有致病性 ,以全身中毒症状为主 ,没有腹泻症状 ,B组较A组发病慢 ,症状轻 ,组织学检查无明显差异 ,两组均于肠腔中分离出相应菌。结论 痢疾杆菌L型仍有致病性 ,致病能力较原菌弱。
Aim To study the pathogenicity of Shigella dysenteriae L forms Methods Convert S dysenteriae into stable L-forms C57BL/6 mice were infected through gastric tubes and state of illness were observed Animals were examined for pathological changes and L-forms isolation after death The experiment was divided into 3 groups:Group A was infected with S dysenteriae original forms,group B with L-forms and group C injected with normal saline Result Pathological changed with systemic intoxication were mainly found in group A and B With no sign of diarrhea The changes were weaker and developed slower in group B than in group A,but the difference was not significant Corresponding pathogens were isolated from each group Conclusion S dysenteriae L-forms are still pathogenic,but much weaker than their original forms
出处
《中国人兽共患病杂志》
CSCD
北大核心
2000年第3期29-30,F003,共3页
Chinese Journal of Zoonoses
基金
安徽省教委资助!课题 (95JL0 1 0 2 )
