摘要
目的探讨活动性与陈旧性静止期肺结核患者血清结合抗体和PPD实验阳性的价值,并分析两者免疫功能指标变化情况。方法选择50例活动性肺结核患者,并与50例陈旧性静止期肺结核患者,比较两组患者血清结核抗体与PPD实验阳性比率,并统计TNF-α、IL-1、IL-6变化情况以及血清CD4、CD8以及CD4/CD8比值。结果活动性肺结核组血清结合抗体阳性和PPD实验阳性的比率均显著高于陈旧性静止期肺结核组(P<0.05),活动性肺结核组TNF-α、IL-1和IL-6水平均显著低于陈旧性静止期肺结核组(P<0.05)。活动性肺结核组CD4、CD8水平均显著低于陈旧性静止期肺结核组(P<0.05),同时CD4/CD8比值显著低于陈旧性静止期肺结核组(P<0.05)。结论活动性肺结核患者体内的炎症细胞因子往往低于静止期,且患者的免疫功能显著下降,出现血清结合抗体和PPD实验阳性的比率显著升高。
Objective To explore the value of positive rates of serum tuberculosis antibody and PPD test in patients with active or static stillness pulmonary tuberculosis （PT）, and to analyze the changes of immune function indicators between active and obsolete PT patients. Methods The positive rates of anti - rnycobacterium tuberculosis antibody and PPD test were compared between 50 patients with active PT and 50 patients with static PT. The changes of TNF- a, IL- 1, IL- 6, CD4, CD8 and the serum ratio of CD4/CD8 were statistically analyzed. Results The positive rates of anti - mycobacteriurn tuberculosis antibody and PPD test in patients with active PT were both significantly higher than those in patients with static ~ （P 〈 0.05）, while the levels of TNF - a, IL - 1, IL - 6, CD4, CD8 and the serum ratio of CD4/CD8 in patients with active PT were all significantly lower than those in patients with static ~ （all P 〈 0.05）. Conclusions Inflammatory cytokines in vivo of patients with active PT are often lower than those in patients with static FF. Active PT patients＇ immune function significantly decreases, meanwhile the positive rates of anti - mycobacterium tuberculosis antibody and PPD test significantly increase.
出处
《实用预防医学》
CAS
2013年第2期246-247,共2页
Practical Preventive Medicine
关键词
活动性
静止性
肺结核
血清抗体
免疫功能
Active
Static
Pulmonary tuberculosis
Serum antibody
Immune function
