摘要
目的探讨活动性结核患者血清炎性因子水平特征及与患者免疫状态的关系。方法选择2003年2月至2005年10月本科住院的结核患者97例,其中活动型结核患者57例,静止期患者40例,对照组为41例健康成年体检者。ELISA法及碱性磷酸酶抗碱性磷酸酶(APAAP)法检测活动性肺结核患者血清中炎性因子水平(TNF-α、IL-1和IL-6)及相关细胞免疫指标(CD4、CD8、CD4/CD8)的变化。结果正常对照组IL-1、IL-6、TNF-α水平分别为(15.3±1.3)、(80.5±7.3)、(77.2±9.8)ng/m l,活动性结核组为(33.7±3.6)、(293.6±30.5)和(190.7±25.2)ng/m l,显著高于正常对照组和静止性结核组。活动性结核组患者外周血CD4比例及CD4/CD8比值为(32.3±2.9)%和(0.83±0.17),显著低于正常对照组。结论炎性因子水平增高及免疫功能下降是活动型结核患者的临床特点之一,两者呈反向依赖关系。
Objective To investigate the changes of inflammatory factors in the blood serum and their relationship with the immune status of patients with active pulmonary tuberculosis （TB）. Methods A total of 97 cases of pulmonary tuberculosis were included from Feb 2003 to Oct 2005, 57 of active TB, 40 in resting period. Another 41 healthy people were used as normal control. ELISA and APAAP method were used to detect the level of TNF-α, IL-1, IL-6 and the changes of CD4, CDsand CD4/CDs. Results The levels of IL-1, IL-6, TNF-α were （15.3 ±1.3）, （80.5 ±7.3） and （77.2 ±9.8） ng/ml in the normal controls, （33.7 ±3.6）, （293.6±30.5） and （190.7 ±25.2） in the patients of active TB, and （18.2 ±2. 1）, （130.7 ±14.5）, （87.5 ± 10.2） ng/ml in the patients at resting period, which were highest in the patients of active TB. The ratio of CD4and CD4/CD8 was （32.3 ±2.9）% and （0.83 ±0. 17） in the patients of active TB, lower than （48. 2 ± 4.4） % and （0.83 ± 0.17 ） of normal controls. Gonclusion The increase of inflammatory factors and decrease of immune activity were the clinical characteristic of patients with active pulmonary tuberculosis, which are of inverse relationship.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2006年第11期1234-1236,共3页
Journal of Third Military Medical University
关键词
结核
炎性因子
免疫
tuberculosis
inflammatory factor
immune
