摘要
阵列生物传感器技术作为一种高通量、快速、选择性高和集成化的分析技术,已在基因组学和蛋白质组学的研究和药物筛选、环境分析,食品分析,临床诊断等领域中得到广泛的应用。阵列生物传感器主要有阵列光学生物传感器和阵列电化学生物传感器。阵列电化学生物传感器是将生物分子识别物质如酶、抗原/抗体、DNA等固定在阵列电极上,以阵列中每根电极产生的电化学信号作为检测信号的电化学分析器件。阵列电化学生物传感器以灵敏度高、分析速度快、选择性好、易于微型化和集成化以及仪器价格低廉等特点受到了研究工作者的极大关注。本文简单介绍了阵列电化学生物传感器的原理和特点,重点评述了2005年以来阵列电化学生物传感器在单组份检测和多组份同时检测两方面的研究进展,简单讨论了阵列电化学生物传感器研究中存在的问题。
Biosensor array such as optical biosensor array and electrochemical biosensor array,has been widely applied in research of genomics and proteomics and in field of drug screening,environmental analysis,food analysis and clinical diagnostics.Electrochemical biosensor array is a promising analytical device that combines immobilized molecular recognition element on surface of multi-electrode array with electrochemical detection signal.It has gained a considerable attention due to high sensitivity,speed,good selectivity,easy miniaturization and integration as well as inexpensive instrument used.The principle and characteristic of electrochemical biosensor array are described herein.The current development of electrochemical biosensor array including single-analyte and multi-analyte since 2005 is reviewed extensively.The current problems and trend of electrochemical biosensor array are briefly discussed.
出处
《现代生物医学进展》
CAS
2012年第35期6988-6991,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(21005003)
关键词
阵列
电化学生物传感器
单组份
多组份
Array
Electrochemical biosensor
Single-analyte
Multi-analyte
