摘要
目的了解幽门螺杆菌(Hp)对临床常用3种抗生素的耐药性,以指导临床合理用药。方法收集上消化道疾病患者胃黏膜标本,分离培养、鉴定出42株Hp临床菌株,采用E-test(Epsilome test)方法测定3种抗生素对Hp菌株的最低抑菌浓度(MIC)。结果 42株临床分离的Hp菌株对甲硝唑、克拉霉素、阿莫西林的耐药率分别为64.3%、14.3%和0。结论 Hp对甲硝唑耐药率高,故甲硝唑不应作为根除Hp感染的一线药物;Hp对克拉霉素耐药率较高,应在药敏监测下选择使用;Hp对阿莫西林敏感,可作为根除Hp感染的主要药物。
Objective The resistivity of Hp to three commonly used antibiotics were investigated, thus guiding the reasonable medication in clinical cases. Methods The specimens were collected from gastric mucous membrane of patients with upper gastrointestinal disease. From these specimens, total 42 Hp strains were isolated, cultivated and identified. The minimum antibacterial concentrations（MIC） of Hp strains to three antibiotics were examined with E-test. Results The average antibiotics resistance rates of 42 Hp strains were estimated as 64.3%, 14.3% and 0 for metronidazole, clarithromyein, and amoxicillin respectively. Conclusions Since clinically isolated Hp is highly resistant to metronidazole, those metronidazole- contained medicines should not be selected as first-choice treatment for Hp infections; It has a high resistivity to clarithromycin, therefore, the latter should be used selectively with drug testing; Hp is sensitive to amoxicillin, hence, the latter should be used as a major medicine for curing Hp infections.
出处
《国际消化病杂志》
CAS
2013年第1期61-63,共3页
International Journal of Digestive Diseases
基金
甘肃省重点中医药科研项目资助(GZK-2009-4)
关键词
幽门螺杆菌
抗生素
耐药性
最小抑菌浓度
Helicobacter pylori
Antibiotics
Resistances
Minimum inhibitory concentration
