摘要
目的 探讨阿莫西林＋呋喃唑酮＋埃索美拉唑镁肠溶片＋枸橼酸铋钾胶囊组成的新四联疗法对幽门螺杆菌（Hp）初治失败患者补救治疗的疗效及安全性。方法 选取2012年1月-2015年1月我院收治的Hp初次根除失败患者200例,随机将其分为观察组和对照组。观察组给予阿莫西林1.0 g＋呋喃唑酮0.1 g＋埃索美拉唑镁肠溶片40 mg＋枸橼酸铋钾胶囊220 mg,口服,2次/d,疗程10 d。对照组给予雷贝拉唑20 mg、果胶铋300 mg、阿莫西林克拉维酸钾1142.5 mg、奥硝唑500 mg,口服,2次/d,疗程10 d。观察两组药物不良反应发生率,停药治疗4周后行14C呼气试验测定Hp。结果观察组意向性治疗（ITT）根除率为95.0%,高于对照组的84.0%,差异有统计学意义（χ2=3.752,P〈0.05）。观察组符合方案治疗（PP）根除率为97.0%,高于对照组的87.0%,差异有统计学意义（χ2=3.811,P〈0.05）;观察组患者3、6个月的复发率明显低于对照组,差异有统计学意义（P〈0.05）;两组的药物不良反应发生率比较差异有统计学意义（χ2=7.031,P〈0.05）;两组的不良反应耐受程度分级差异有统计学意义（P〈0.05）。结论 由阿莫西林＋呋喃唑酮＋埃索美拉唑镁肠溶片＋枸橼酸铋钾胶囊组成的新四联疗法是一种Hp初治失败后安全而有效的补救治疗方案。
Objective To explore the effect and safety of new quadri-combination therapy including Amoxicillin,Fura- zolidone,Esomeprazole Magnesium Enteric-Coated Tablets and Bismuth Potassium Citrate Capsules in remedial treat- ment Helicobacter pylori （Hp） in the early cure failure. Methods 200 Hp in the early cure remedial treatment failure patients from January 2012 to January 2015 were selected and patients were random divided into observation group and control group.Patients in observation group were given Amoxicillin 1.0 g,Furazolidone 0.1 g,Esomeprazole Magnesium Enteric-Coated Tablets 40 mg and Bismuth Potassium Citrate Capsules 220 mg,twice a day for 10 days.Patients in con- trol group were given Rabeprazole 20 mg,Colloid.al Bismuth Pectin 300 mg,Amoxicillin and Clavulanate Potassium 1142.5 mg and Ornidazole 500 mg by oral,twice a day for 10 days.The incidence rate of drugs was observed.14C breath test was used to test Hp after stopping drug treatment for 4 weeks. ,Results The ITT eradication rate in observation group was 95.0%,which was higher than that was 84.0% in control group,and the difference was statistical significance （X2=3.752,P〈0.05）.The PP eradication rate in observation group was 97.0%,which was higher than that was 87.0% in control group,and the difference was statistical significance （X2=3.811, P〈0.05）.The recurrence rate in observation group obvious lower than control group in 3 and 6 months,and the difference was statistical significance （P〈0.05）.The inci- dence rate of drug adverse effects between two groups had statistical significance （X2=7.031, P〈0.05）.Tolerance classifi- cation of drug adverse effects between two groups had statistical significance （P〈0.05）. Conclusion A new quadri-com- bination therapy including Amoxieillin,Furazolidone,Esomeprazole Magnesium Enteric-Coated Tablets and Bismuth Potassium Citrate Capsules is a safety and effective rescue therapy method for Ho treated first failure.
出处
《中国当代医药》
2016年第13期141-144,共4页
China Modern Medicine
关键词
阿莫西林
呋喃唑酮
埃索美拉唑镁肠溶片
枸橼酸铋钾胶囊
幽门螺杆菌
Amoxicillin
Furazolidone
Esomeprazole Magnesium Enteric-Coated Tablets
Bismuth Potassium CitrateCapsules
Helicobacter pylori
