摘要
目的探讨乳头状肾细胞癌(PRCC)病理分型对评估病情、判断预后的意义。方法回顾性分析本院35例乳头状肾细胞癌的资料,根据WHO肾肿瘤组织学分型分为I型和II型,对其临床特征和病理检查情况进行分析。结果 PRCC I型19例,占54.29%;II型16例,占45.71%。II型组肿瘤分级、分期和血管侵犯率均高于I型组,差异有统计学意义(P<0.05)。而两组患者的年龄、性别、肿瘤部位和肿瘤直径比较,差异无统计学意义(P>0.05)。免疫组化检查结果显示,I型PRCC的细胞角蛋白7(CK7)阳性率为100%(19/19),II型CK7阳性率为43.75%(7/16),两组差异有统计学意义(P<0.05)。结论乳头状肾细胞癌病理诊断分型对患者的临床病情评估有指导作用。
JIN Long, LIN Jie, CHEN Xiaoyan , SUI Yuxia. Department of Pathology, Fujian Provincial Hospital, Provincial Clinical Medical College of Fu- jian Medical University, Fuzhou, Fujian 350001, China [Abstract] Objective To investigate the clinicopathological characteristics in two type of papillary renal cell carcinoma （PRCC） and their clinical significance. Methods The data on 35 cases of PRCC were analyzed. According to the 2004 World Health Organization histological classification, carcinomas in 35 patients were classified as type I and II. The clinicopathologi- cal characteristics in two type of PRCC were analyzed statistically. Results Pathologically, 19 patients （54.29%） and 16 pa dents （45.71%） were diagnosed with type I and type H PRCC, respectively. The type ]] patients had a significantly higher tumor grade （P〈0.05）, a more advanced stage （P〈0.05）, and more frequent vascular invasion （P〈0.05） compared to the type I PRCC patients. Immunohistochemistry showed that the expression of CK7 in type I PRCC was 100% （19/19）, while in type II 43.75% （7/16）, with statistical significance （P〈0.05）. Conclusion The morphological subtyping of PRCC is signifi- cantly associated with clinicopathological features. Dividing PRCC into two subtypes has practical guidance to evaluate patients condition.
出处
《福建医药杂志》
CAS
2013年第1期67-69,共3页
Fujian Medical Journal
关键词
形态学
乳头状肾细胞癌
I型
II型
morphology
papillary renal cell carcinoma
type I
type I]
