摘要
目的评价1-6二磷酸果糖联合黄芪注射液治疗病毒性心肌炎的疗效。方法计算机检索Cochrane图书馆临床对照试验资料库、MEDLINE、EMbase、万方、维普、CNKI、CBM,手工检索1-6二磷酸果糖联合黄芪注射液治疗病毒性心肌炎1995年3月—2011年12月发表的相关文献,应用Rev Man 5.0软件对数据进行Meta分析。结果试验组患者症状缓解与对照组相比差异有统计学意义[Z=5.66(P<0.001),比值比(OR)=5.65,95%CI(3.10,10.30)];心电图改善总有效率试验组均高于对照组,差异有统计学意义[Z=3.31(P=0.000 9),OR=3.81,95%CI(1.73,8.43)];肌酸激酶同工酶的降低试验组均优于对照组,差异有统计学意义[加权均属差(WMD)=-9.27,95%CI(-78.17,-4.47),P=0.000 2]。漏斗图近似对称,发表偏倚不大。结论 1-6二磷酸果糖联合黄芪注射液治疗病毒性心肌炎在临床症状改善、心电图改善、降低心肌肌酸激酶同工酶方面疗效确切。
Objective To evaluate the effectiveness of fructose diphosphate sodium （FDP） combined with astragalus membranaceus in treatment of vital myocarditis （VMC）. Methods The related literature of fructose diphosphate sodium （FDP） combined with astragalus membranaceus in treatment of viral myocarditis were searched by computer from electronic database of Co- chrane controlled clinical trials data bank, MEDLINE, EMbase, Wanfang Data, CQVIP database, China know nets （CNKI） and China biological medical literature database （CBM）, and were searched by hand during March 1995 and December 2011. All the data were processed by meta analysis using Review manager 5.0. Results There were significant differences in patients＇symptomatic relief between therapy group and control group [Z = 5.66 （P 〈0.001） , OR =5.65, 95% CI （3.10,10.30）]; the total effective rate of electrocardiogram curative effect in therapy group was significantly higher than that of control group [ Z = 3.31 （ P =0. 000 9）, OR =3.81, 95% CI （1.73,8.43）1; the decrease of CK-MB isoenzyme in therapy group was more obvious than that of control group [ WMD = - 9.27, 95% CI （ - 78.17, - 4.47 ）, P = 0. 000 21- The funnel schema was nearly symmetry with little bias. Conclusion The method of FDP combined with astragalus membranaceus in treatment of viral myocarditis may be effective in clini- cal symptoms improvement, electrocardiogram improvement and the myocardial CK-MB isoenzyme reduction.
出处
《临床误诊误治》
2013年第2期71-76,共6页
Clinical Misdiagnosis & Mistherapy
关键词
1-6二磷酸果糖
黄芪注射液
病毒性心肌炎
META分析
Fructose diphosphate sodium
Astragalus membranaceus parenteral solution
Viral myocarditis
Meta analysis
