摘要
目的研究超微粉碎技术对残黄片溶出度的影响。方法采用超微粉碎技术对原料药材进行粉碎,压片,以盐酸溶液(pH 1.0)为溶出介质,采用桨法测定体外溶出度,比较基于超微粉碎技术的残黄片和普通粉碎的残黄片的溶出速率和溶出量。结果基于超微粉碎技术的残黄片的体外累积溶出率相比基于普通粉碎的残黄片有显著提高。结论超微粉碎技术工艺简单易行,可提高残黄片有效成分的溶出。
Objective To study the effect of ultrafine powder technology on the dissolution of Canhuang tablets. Methods Raw medicinal materials were crushed using ultrafine powder technology and subsequently pressed into tablets. With hydrochloric acid solution （ pH 1.0） as the dissolvent, the dissolution rate and amount of berberine hydro chloride from the Canhuang tablets based on ultrafine powder as well as ordinary powder were determined and compared using the paddle method. Results The accumulated dissolution of Canhuang tablets in vitro based on ultrafine powder is significantly higher than that of ordinary powder tablets. Conclusion Ultrafine powder technology is feasible and can improve the dissolution rate markedly in vitro.
出处
《解放军药学学报》
CAS
2012年第6期506-508,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
军队十二五中医药重点课题
No.20100124
关键词
残黄片
超微粉碎技术
溶出度
Canhuang tablets
uhrafine powder
dissolution
