摘要
目的探讨准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)使用飞秒激光制瓣对近视患者角膜生物力学各指标和眼压的影响。方法选取111例(222眼)近视患者均行飞秒激光LASIK。分别于术前、术后3个月应用眼反应分析仪检测角膜补偿眼压(corneal compensated intraocular pressure,IOPcc)、模拟Goldmann眼压(Goldmann correlated IOP value,IOPg)、角膜阻力因子(corneal resistance factor,CRF)、角膜滞后量(corneal hysteresis,CH),A型超声测量角膜厚度。比较术后3个月与术前各测量值的差异。结果术后3个月角膜厚度为(444.00±35.31)μm与术前(536.86±27.09)μm比较,差异有显著统计学意义(t=-55.08,P=0.000),切削深度(92.85±25.12)μm。术后3个月IOPcc、IOPg分别为(14.05±2.32)mmHg(1kPa=7.5mmHg)、(10.00±2.55)mmHg,较术前(16.03±3.33)mmHg、(14.96±3.32)mmHg显著降低(t分别为-11.111、-24.792,P分别为0.000、0.000)。IOPcc、IOPg分别较术前降低(1.98±2.66)mmHg、(4.95±2.98)mmHg。CRF、CH术后测量值(6.54±1.39)mmHg、(7.77±1.23)mmHg较术前(9.90±1.83)mmHg、(9.92±1.62)mmHg显著降低(t分别为-27.976、-21.773,P分别为0.000、0.000)。CRF、CH分别较术前降低(3.36±1.79)mmHg、(2.15±1.47)mmHg。角膜切削厚度与CRF、CH改变量呈正相关(r=0.246、0.166,P=0.000、0.013)。结论飞秒激光LASIK术后角膜生物力学各指标和眼压均较术前显著降低,角膜生物力学改变与切削量有关。
Objective To discuss the effects of femtosecond LDV laser flapping in laser in situ keratomileusis （ LASIK） on corneal biomechanics and intraocular pressure （ IOP） .Methods One hundred and eleven myopic patients （ 222 eyes） were underwent femtosecond LASIK.The corneal compensated intraocular pressure （ IOPcc） ,Goldmann correlated IOP value （ IOPg） ,corneal resistance factor （ CRF） and corneal hysteresis （ CH） before operation and 3 months after operation were examined by ocular response analyzer,the corneal thickness was measured by A ultrasound.The differences before and after operation were compared.Results The preoperative and postoperative central corneal thickness were （ 536.86±27.09 ） μm and （ 444.00±35.31） μm,there was statistical difference（ t = - 55.08,P = 0.000） ,the difference was （ 92.85±25.12） μm.IOPcc and IOPg at postoperative 3 months were （ 14.05±2.32） mmHg（ 1kPa = 7.5 mmHg） and （ 10.00±2.55） mmHg,which were significant lower than pre-operation [（ 16.03±3.33 ） mmHg,（ 14.96±3.32 ） mmHg],there were statistical differences（ t = - 11.111,- 24.792; P = 0.000,0.000 ） , the differences were（ 1.98±2.66 ） mmHg,（ 4.95±2.98 ） mmHg,respectively.CRF and CH at postoperative 3 months were （ 6.54±1.39） mmHg,（ 7.77±1.23） mmHg,which were significant lower than pre-operation [（ 9.90±1.83 ） mmHg,（ 9.92±1.62 ） mmHg],there were statistical differences（ t = - 27.976,- 21.773; P = 0.000,0.000 ） ,the differences were （ 3.66±1.79 ） mmHg and （ 2.15±1.47 ） mmHg,respectively.The corneal remotion thickness was positive correlated with CRF and CH（ r = 0.246,0.166; P = 0.000,0.013） .Conclusion The corneal biomechanics and IOP after femtosecond LASIK were lower than pre-operation.The changes in corneal biomechanics are related to the corneal thickness.
出处
《眼科新进展》
CAS
北大核心
2013年第2期175-177,共3页
Recent Advances in Ophthalmology
关键词
飞秒激光
角膜厚度
角膜生物力学
femtosecond laser
corneal thickness
corneal biomechanics
