摘要
目的 研究妊娠期高血压疾病与血清游离雌三醇（FE3）水平之间的相关性及其对妊娠结局的影响。方法 回顾性分析117例妊娠期高血压疾病孕妇（观察组）和165例同期正常孕妇（对照组）的临床资料,化学发光免疫分析法测定孕妇血清中FE3的含量,分析妊娠期高血压疾病与FE3之间的相关性和对妊娠结局的影响。结果 观察组低密度脂蛋白胆固醇和肌酐显著低于对照组（t=3.129、9.372,P〈0.05）,而血压、高密度脂蛋白胆固醇和24 h 尿蛋白含量则显著高于对照组（t=7.361、2.389、2.833,均P〈0.05）。观察组的FE3水平显著低于对照组（t=2.913,P〈0.05）,而正常孕妇FE3水平则和孕周成显著正相关性（r=0.937,P〈0.05）。观察组孕妇发生早产、胎膜早破、产后出血、新生儿窒息情况的概率显著高于对照组（χ2=3.912、3.879、4.267、6.935,均P〈0.05）。结论 妊娠期高血压疾病与FE3之间具有显著的相关性,这对于孕妇孕期的健康状况尤其是胎儿-胎盘功能的检测具有重要意义。
Objective To research the relationship between hypertensive disorder complicating pregnancy and serum free estriol 3 （FE3） and explore its impact on pregnancy outcome.Methods Clinical data of 117 hypertensive disorder complicating pregnancy and 165 normal pregnant women were retrospectivly analyzed.Chemiluminescence immunoassay determination of maternal serum FE3 also had been conducted.Then analyzing the correlation between hypertensive disorder complicating pregnancy and FE3 and its impact on pregnancy outcomes.Results LDL cholesterol and the level of creatinine of observation group were significantly lower than the control group（t=3.129,9.372,all P〈0.05）,while blood pressure,triglycerides,HDL,and 24-hour urinary protein content were significantly higher than control groug（t=7.361,2.398,2.833,all P〈0.05）.The FE3 level of the observation group were significantly lower than the control group（t=2.913,P〈0.05）.There was a significant positive correlation between the FE3 level of normal pregnant women and their gestational age（r=0.937,P〈0.05）.The probabilities of premature birth,premature rupture of membranes,postpartum hemorrhage,and neonatal asphyxia of observation group were significantly higher than amtrol group（χ2=3.912,3.879,4.267,6.935,all P〈0.05）. Conclusion There is a significant correlation between hypertensive disorder complicating pregnancy and FE3,which has an important significance on monitoring the health status of pregnant women and the fetal-placental function.
出处
《中国基层医药》
CAS
2013年第1期11-13,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
妊娠并发症
心血管
雌三醇
妊娠结局
Pregnancy complications,cardiovascular
Estriol
Pregnancy outcome
