摘要
目的:考察盐酸法舒地尔(简称法舒地尔)与注射用盐酸川芎嗪(简称川芎嗪)的配伍稳定性。方法:采用HPLC法,测定室温(25℃)条件下8 h内配伍溶液中两药的含量变化,并考察配伍前后外观、性状、pH及无增加不溶性微粒的变化。结果:注射用盐酸法舒地尔与川芎嗪配伍后在室温下放置8 h,配伍溶液的外观、性状、pH无明显变化,不溶性微粒无增加,放置8 h两药的含量仍在97%以上。结论:盐酸法舒地尔注射液与注射用盐酸川芎嗪配伍8 h内稳定。
Objective：To study the compatibility of fasudil injections and ligustrazine injections.Method：The changes in pH value,appearance and insoluble particles were observed,and the relative contents were determined by HPLC in 8h after the compatibility at room temperature.Result：There were no significant changes in pH value,appearance and relative contents of fasudil and ligustrazine for injection in 8h,and there waere no increasing in insoluble particles after the compatibility.The relative contents of the drugs were above 97%in 8h.Conclusion：Fasudil injections are compatible with ligustrazine injections in 8h at room temperature.
出处
《中国药师》
CAS
2012年第12期1751-1753,共3页
China Pharmacist
