摘要
目的采用Ⅱ型ZTC1+1天然澄清剂,建立百瑞口服液的澄清工艺。方法考察澄清剂的加入顺序、加入量、澄清时间对口服液澄明度的影响;采用HPLC法测定口服液中紫云英苷含量,采用紫外分光光度法测定口服液中总黄酮含量。结果确定了口服液的澄清工艺:以先B组分后A组分的次序加入20%的澄清剂,各组分的澄清时间均为12 h。结论 ZTC1+1天然澄清剂不影响紫云英苷及总黄酮等有效成分的含量,可作为制备百瑞口服液的除杂澄清工艺。
Objective To establish a optimum clarification process of Bairui oral liquid with new ZTCI ＋ 1-Ⅱ natural clarif- ying agents. Methods The effects on clarification of Bairui oral liquid were evaluated based on the factors such as adding sequence, added amount and clarification time of ZTC1 ＋ 1-Ⅱ clarifiers A and B. The contents of astragalin and total flavones were determinate by the HPLC and UV methods respectively to evaluate the removing activities of ZTC1 ＋ 1 - Ⅱ on active components. Results The selected clarification process conditions were ： adding 20% percentage of each components of ZTCI ＋ 1 -Ⅱ to the condensed herb extract solutiml, the adding sequence was clarifiers B before clarifiers A, and the elarifieation time was 12 b, respectively. Conclusion The contents of astragalin and total flavones were not decreased by clarification pr0cess, ZTC1 ＋ 1- Ⅱ could be used as the removing impurity of Bairui oral liquid.
出处
《药学实践杂志》
CAS
2013年第1期32-34,共3页
Journal of Pharmaceutical Practice
基金
上海市卫生局局级科研课题(2012085号)
关键词
百蕊草
口服液
ZTC1+1-Ⅱ
澄清工艺
Thesium chineusis Turcz
oral liquid
ZTCI ＋ 1 -Ⅱ
clarification process
