摘要
目的本研究的目的是探索尿BNP与血浆BNP是否存在相关性,及其在心力衰竭中是否有诊断价值。方法本研究纳入45例心力衰竭患者及25例健康对照组。检测尿BNP和血浆BNP。对心力衰竭患者进行心功能分级。结果心力衰竭组尿液BNP均值为154.5±82.1pg/ml,对照组为24.8±9.0pg/ml,两组间有明显差异(P=0.000)。尿液BNP和血浆BNP、心功能分级存在相关性。尿液BNP的截点值为34.5pg/ml时,其特异性和敏感度分别为88.9%和92.0%。结论尿液BNP检测有助于诊断心力衰竭及判断心力衰竭的严重程度。
Objective To evaluate the value of urinay B Type natriuretic peptide （BNP） in the diagnosis of heart failure, and study the correlation between urinary BNP and plasma BNP. Methods We studied 45 patients with heart failure and 25 healthy controls. All the patients＇ and controls＇ urinary and plasma were detected. The patients＇ heart function was classified according to NYHA system. Results Average urinary BNP Ievels were 154.5 ± 82. lpg/ml in heart failure group and 24.8 ±9. Opg/ml in the controls （ t = 7.52, P 〈 0. 0001 ）. Urinary BNP was correlated with plasma BNP and NYHA grades of heart failure. The optimal cutoff value for urinary BNP was 34.5pg/ml. Its specificity and sensitivity were 88.9% and 92.0% , respectively. Conclusion Measurement of urinary BNP is applica- ble in clinical diagnosis of heart failure and judgement of heart function.
出处
《医学研究杂志》
2013年第1期162-166,共5页
Journal of Medical Research
关键词
B型利钠肽
心力衰竭
尿液
B - type natriuretic peptide
Heart failure
Urine
