摘要
目的观察益心泰对心肌梗死后大鼠左室重构的影响。方法制备心肌梗死大鼠模型。随机分为模型组、益心泰组、开博通组、复方丹参滴丸组和假手术组。模型组和假手术组以蒸馏水等量灌胃,其余各组分别给予相应药物灌胃。用药8周后分别检测左、右心室质量指数及梗死区室壁厚度、室间隔厚度、梗死区面积百分比、心肌纤维直径。结果与假手术组比较,模型组左、右心室质量指数明显增加(P<0.01);与模型组比较,益心泰组、复方丹参滴丸组和开博通组左、右室质量指数均降低(P<0.01);而益心泰组、复方丹参滴丸组和开博通组各指标比较差异无统计学意义。与假手术组比较,模型组梗死区室壁厚度、室间隔厚度明显降低(P<0.01),梗死区面积百分比明显增加(P<0.01);与模型组比较,益心泰组、复方丹参滴丸组和开博通组梗死区室壁厚度、室间隔厚度均增加(P<0.01),梗死区面积百分比降低(P<0.01)。与假手术组比较,模型组心肌纤维直径明显增加(P<0.01);与模型组比较,益心泰组、复方丹参滴丸组和开博通组心肌纤维直径均降低(P<0.01)。结论益心泰丸在一定程度上干预了心肌梗死后大鼠的心室重构。
Objective To explore the effect of Yixintai on left ventricular reconstruction of myocardial infarction rats.Methods Myocardial infarction rat model was made.Rats was randomly divided into model group,Yixintai group,Captopril group,compound danshen dripping pills group and sham operation group.The model group and sham operation group were given equivalent distilled water by lavage,the other groups were given corresponding drug.After eight weeks,left and right ventricular weight index,infarction area chamber wall thickness and interventricular septum thickness,infarction area percentage and myocardial fiber diameter were detected.Results Compared with sham operation group,left and right ventricular weight index of model group increased（P〈0.01）.Compared with the model group,left and right ventricular weight index of Yixintai group,compound danshen dripping pills group and Captopril group were lowered（P〈0.01）.The difference in these indexes among Yixintai group,compound danshen dripping pills group and Captopril group was not significant.Compared with sham operation group,infarction area chamber wall thickness and interventricular septum thickness of model group decreased obviously（P〈0.01）,infarction area percentage increased significantly（P〈0.01）.Compared with the model group,infarction area chamber wall thickness and interventricular septum thickness of Yixintai group,compound danshen dripping pills group and Captopril group were high（P〈0.01）,infarction area percentage were low（P〈0.01）.Compared with sham operation group,model group significantly increased myocardial fiber diameter（P〈0.01）.Compared with the model group,myocardial fiber diameter of Yixintai group,compound danshen dripping pills group and Captopril group were low（P〈0.01）.Conclusion Yixintai can intervene left ventricular reconstruction of myocardial infarction rats to some extent.
出处
《中国中医药信息杂志》
CAS
CSCD
2013年第1期47-49,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
湖南省科技计划项目(2009JT3040)
关键词
益心泰丸
心肌梗死
心室重构
大鼠
Yixintai
myocardial infarction
ventricular remodeling
rats
