摘要
目的观察养心康对慢性心功能不全模型兔心室重构的影响。方法将25只新西兰兔造模成功后随机分为5组,即模型组,卡托普利组(1.2 mg.kg-1),养心康高、中、低剂量组(1.53,0.51,0.17 g.kg-)1,并设立空白对照组,每组5只。应用结扎兔冠状动脉的方法建立兔慢性心力衰竭模型,灌胃给药,每日一次,连续4周。观察兔心功能、心脏指数、室壁厚度和心肌细胞凋亡的情况。结果各给药组的心功能、心脏指数、室壁厚度和心肌细胞凋亡指数均有明显的改善,与模型组比较,有显著性差异(P<0.05或P<0.01)。结论养心康可以防治心衰模型兔的心室重构。
Objective To observe the effects of Yangxinkang on ventricular remodeling of the rabbit model with chronic heart failure.Methods The rabbit model of chronic heart failure was establised by ligation of left anterior descending coronary artery.Twenty-five New Zealand modeled rabbits were divided into model group,Captopril group（1.2 mg·kg-1）,and low-dose,middle-dose and high-dose Yangxinkang groups（in the dosage of 1.53,0.51,0.17 g·kg-1,respectively）.Five heathy rabbits served as the blank control group.The medication was carried out by intragastric administration once a day and for a total of 4 weeks.The effects of Yangxinkang on cardiac function,cardiac index,left ventricular wall thickness and myocardial cell apoptosis of the rabbit model were investigated.Results The cardiac function,cardiac index,left ventricular wall thickness and myocardial cell apoptosis of the administration groups were significantly improved,and the differences were statistically significant compared with model group（P 0.05 or P 0.01）.Conclusion Yangxinkang can prevent ventricular remodeling of the rabbit model with chronic heart failure.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2012年第1期58-60,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广州市科技局资助项目(2008A1-E4101)
关键词
养心康
慢性心功能不全
心脏指数
心室重构
兔
Yangxinkang
Chronic heart failure
Cardiac index
Ventricular remodeling
Rabbits
