摘要
近年来，随着医学相关学科的迅猛发展，组织工程技术已经取得了很大的成就，但种子细胞一直是困扰人们的焦点问题。脂肪干细胞（ADSCs）体外扩增迅速，稳定性好，无免疫排斥反应，具有多向分化潜能，可以向脂肪细胞、成骨细胞、成软骨细胞、内皮细胞、肌细胞和神经细胞等不同胚层来源的细胞分化，并且脂肪组织具有取材方便、对人体创伤小、可大量获得等优点，因而ADSCs有望成为一种理想的组织工程种子细胞。旨在介绍ADSCs在骨软骨组织工程中的研究进展。
With the rapid development of medical sciences in recent years, tissue engineering technology has made great achievements, while the choosing of seed cells has been a major focus of the field. Adipose-derived cells have the advantages of rapid expansion, good stability, no immune rejection and potential of multiplex differentiation. They can differentiate into cells originated from different germ layers such as： adipocytes, osteoblasts, chondrocytes, endothelial cells, myocytes, neuronal cells and so on. Besides, adipose tissue can be harvested easily and substantially with small trauma to human body. So ADSCs are expected to be an ideal choice of seed cells in tissue engineering. This article introduces the research progress of ADSCs in osteochondral tissue engineering .
出处
《国际生物医学工程杂志》
CAS
2012年第6期361-364,共4页
International Journal of Biomedical Engineering
基金
国家自然科学基金资助项目（31000432）
天津市卫生局科技基金重点资助项目（2010KR08）
关键词
脂肪干细胞
骨软骨
组织工程
Adipose-derived stem cells
Osteochondral
Tissue engineering
