摘要
目的观察舒芬太尼对家兔心肌缺血再灌注后心功能的影响并探讨其作用机制,为临床合理用药提供实验依据。方法 24只家兔随机分为3组:对照组、舒芬太尼组、纳络酮-舒芬太尼组,于缺血再灌注各个时期测定心功能指标。结果左室收缩峰压(LVSP)、左室发展压(LVDP)和心室收缩的最大速率(±dp/dt)缺血期明显降低,左室舒张末压(LVEDP)明显升高。而LVSP、LVDP和±dp/dt于心肌再灌注后未再进一步下降。而是随时间延长逐渐恢复并明显好转。结论心肌缺血再灌注对兔心功能有明显抑制,舒芬太尼能明显改善心脏功能,纳络酮可部分取消舒芬太尼的心肌保护作用。
Objective To observe the effects sufentanil on myocardial ischemia reperfusion cardiac function in rabbits and discuss the mechanism for clinical rational drug use,to provide the basis.Methods 24 rabbits were divided into three groups： control,sufentanil group,ketone,winding sufentanil group,each period in ischemia-reperfusion determination cardiac index.Results LVDP and LVSP,±dp/dt ischemia period LVEDP reduced significantly,and increased significantly.And LVDP and LVSP,± dp/dt in myocardial reperfusion not drops further,and after recovery started the trend.Conclusion Myocardial ischemia reperfusion to the rabbit cardiac had significant inhibitory,sufentanil can significantly improve cardiac function,as partial cancellation collaterals ketone of sufentanil myocardial protection.
出处
《中国医药指南》
2012年第36期407-408,共2页
Guide of China Medicine
关键词
心肌缺血再灌注
舒芬太尼
心功能
Myocardial ischemia reperfusion
Sufentanil
Cardiac function
