摘要
目的研究利多卡因对家兔缺血再灌注心肌NF-κB表达及血浆ICAM-1、IL-8水平的影响。方法 18只家兔随机分为3组(每组6只),假手术组、缺血再灌注组和利多卡因组。测定各组家兔血浆ICAM-1、IL-8的水平,免疫组化方法观察心肌NF-κB表达情况。结果与缺血再灌注组比较,利多卡因后处理组再灌注后血浆ICAM-1和IL-8浓度明显低于缺血再灌注组(P<0.01),利多卡因可抑制心肌细胞NF-κB的表达。结论利多卡因可以抑制ICAM-1、IL-8的释放及NF-κB的表达,减轻家兔心肌缺血再灌注后炎性反应。
Objective To investigate the effects of lidocaine on myocardial NF-κB expression and plasma ICAM-1,IL-8 levels following myocardial ischemia reperfusion in rabbits.Methods Eighteen rabbits were randomly divided into 3 groups（n= 6 each）：sham operation group,ischemic reperfusion group and lidocaine group.The levels of ICAM-1 and IL-8 in plasma were measured,and the degree of myocardial NF-κB expression was observed by immunohistochemical method.Results Compared with those of ischemic reperfusion group,ICAM-1 and IL-8 concentrations in lidocaine group were significantly lower（P0.01）.Lidocaine also reduced myocardial NF-κB expression.Conclusion Lidocaine could suppress plasma IL-8 and ICAM-1 levels and myocardial NF-κB expression,and alleviate inflammatory response induced by myocardial ischemia reperfusion.
出处
《济宁医学院学报》
2012年第6期399-401,共3页
Journal of Jining Medical University
基金
济宁市2009年科技局项目
