摘要
目的:探讨难治复发性淋巴瘤患者细胞免疫、红细胞免疫及肿瘤标志物的变化规律。方法:选取2009年7月～2012年6月于本院进行治疗的25例难治复发性淋巴瘤患者为观察组,同期的25例治疗有效患者为对照组,检查并比较两组患者的细胞免疫、红细胞免疫及肿瘤标志物水平。结果:观察组的CD3+、CD4+、CD4/CD8及NK均低于对照组,CD8+水平高于对照组,红细胞C3bs受体(RBC-C3bR)及红细胞免疫促进因子(RFER)均低于对照组,红细胞免疫复合花环(RBC-ICR)及红细胞免疫抑制率(RFIR)高于对照组,肿瘤标志物癌胚抗原(CEA)、肿瘤相关因子抗原125(CA125)/组织多肽特异性抗原(TBS)、β2-微球蛋白(β2-MG)水平均高于对照组,且Ⅲ～Ⅳ期患者变化幅度均大于Ⅰ～Ⅱ期患者,差异均有统计学差异(P均<0.05)。结论:难治复发性淋巴瘤患者的免疫状态较低,且肿瘤标志物水平较高。
Objective. To study the variation of cellular immunity, red cell immune and tumor markers of patients with relapsed and refractory lymphoma. Methods.A total of 25 patients with relapsed and refractory lymphoma admitted in our hospital from July 2009 to June 2012 were selected as observation group, and 25 patients who were effectively treated at the same time were selected as control group. Cellu- lar immunity, red cell immune and tumor markers of two groups were detected and compared. Results. CD3＋ ,CD4＋ ,CD4/CD8 and NK of observation group were lower than those of control group, CD8＋ were higher than those of control group, RBC -C3bR and RFER were lower than those of control group, RBC- ICR and RFIR were higher than those of control group, serum tumor markers were all higher than those ofcontrol group,and the those items change range of stage Ⅲand Ⅳ wer Ⅱ（all P^0.05）. Oonelusions. The immune state of patients with rel poor,and their tumor markers are higher. e greater than those of stage I and apsed and refractory lymphoma is
出处
《海南医学院学报》
CAS
2013年第1期61-63,67,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210477)~~
