摘要
目的 探讨骨肉瘤患者红细胞免疫功能状态与T淋巴细胞亚群改变的关系。方法 测定35例骨肉瘤患者红细胞补体受体花环率 (C3 bRR)、红细胞免疫复合物花环率 (RICR)、红细胞免疫促进因子 (RFER)、红细胞免疫抑制因子 (RFIR)和T淋巴细胞亚群 (CD3 、CD4 、CD8)的功能状态。结果 骨肉瘤患者C3 bRR、RFER、CD3 、CD4 较正常对照组降低 (P <0 0 5 ) ,而RICR、RFIR、CD8则较正常对照组升高 (P <0 0 5 )。骨肉瘤患者C3 bRR与CD4 /CD8比值呈正相关。结论 骨肉瘤患者红细胞免疫功能低下 ,T淋巴细胞亚群比例失调 。
Objective To study immune function of erythrocytes and its correlation with the change of T lymphocyte subsets in patients with osteosarcoma. Methods The red blood cell(RBC), C 3b receptor rate (C 3bRR),immune complex rate(RICR),immune adherence enhance factor (RFER),immune adherence inhibitor factor(RFIR) and the subsets of T lymphocyte were determined in 35 cases of osteosarcoma. Results The C 3bRR,RFER,CD 3,CD 4 and CD 4/CD 8 ratio was lower in the osteosarcoma group than in the control one ( P <0 05). Meanwhile, RICR、RFIR、 and CD 8 were significantly elevated ( P <0 05). A positive correlation between C 3bRR and the ratio of CD 4/CD 8 was found in the osteosarcoma group. Conclusion Patients with osteosarcoma show lower erythrocyte function and disorder of T lymphocyte subsets. There is a close relationship between RBC immune function and T lymphocyte subsets.
出处
《临床骨科杂志》
2000年第2期83-84,共2页
Journal of Clinical Orthopaedics
