摘要
目的回顾性分析1989—2010年全国范围内志贺菌属的药物耐药情况和血清群分布特征,为细菌性痢疾的临床合理用药和预防控制工作提供依据。方法检索中国知网中国期刊全文数据库1989—2010年关于全国各地区志贺菌属耐药情况和血清群分布数据的全部文献,按照地区和时间跨度分组,分别进行统计学分析。结果全国范围内志贺菌属对多种抗生素的耐药性在2000年后呈显著增加的趋势,且同一年代内南北方相比差异有统计学意义。1989—2010年全国范围内志贺菌属血清群分布始终以福氏志贺菌(B群)为主,宋内志贺菌(D群)次之。2000年后,南方D群构成比显著上升;北京D群构成比20年来始终明显高于上海。结论全国范围内志贺菌属的耐药性持续增加,血清群分布发生变化。
Objective The characteristics of serotype distribution and antibiotic resistance of Shigella spp. were investigated retrospectively to provide theoretical basis of clinical use of drugs and prevention and control in the bacillary dysentery （shigellosis）. Methods The China Knowledge Resources Integral Databases were searched from 1989 to 2010 to record and analyze data on the antimicrobial resistance and serotype distribution of Shigella spp. Results The resistance rate showed a significant increase to most antibiotics after 2000, and was significantly different between North China and South China during the same period. For the serotype distribution of Shigella spp. from 1989 to 2010, Shigella Flexneri （group B） was always the most frequently isolated serogroup, followed by Shigella sonnei （group D）. After 2000, there was a significant upward trend in the constituent ratio of group D in south China. And the constituent ratio of group D was always significantly higher in Beijing than that in Shanghai during the past 20 years. Conclusion With the abuse of antibiotics, the drug resistance of Shigella spp. continues to increase, and serotype distribution changes96 in both north and south China.
出处
《天津医药》
CAS
北大核心
2013年第1期80-82,共3页
Tianjin Medical Journal
