摘要
目的了解合肥省志贺菌属的分布及耐药情况,以指导临床合理用药。方法采用国际标准平皿琼脂对倍稀释法测定合肥省35所医院2005年9月份收集的91株志贺菌属对多种抗菌药物的敏感性,用生化和血清学方法鉴定血清群。结果91株志贺菌属中,有弗氏志贺菌57株、宋内志贺菌31株、鲍氏志贺菌3株;91株志贺菌属对头孢哌酮/舒巴坦和哌拉西林/他唑巴坦的耐药率,明显低于其他头孢类抗菌药物,对碳青酶烯类敏感率达100%,对氟喹诺酮类环丙沙星及帕珠沙星的耐药率分别是27.47%、32.97%。结论合肥省志贺菌属对喹诺酮类和三代头孢类抗菌药物有一定耐药性,应加强耐药性监测和防治。
OBJECTIVE To investigate the distribution and the resistance rate of Shigella in Anhui Province to guide the choice of antibacterials, METHODS Ninety one strains of Shigella were cultured in Sep 2005. The groups were identified by biochemical and serologic tests. Susceptibility of 91 strains of Shigella in Anhui to various antibiotics was tested using standardized custom dilution MIC panels according to CLSI（2005） guidelines. RESULTS There were 57 strains of Shigella flexneri, 31 strains of S. sonnei and 2 strains of S. boydii among 91 strains of Shigella. The resistance rates of Shigella to cefoperazone/sulbactam and piperacillin/tazobactam were remarkably lower than to other third generation cephalosporins. The susceptible rates to carbopenems were 100%. The resistance rates to ciprofloxacin lactate and pazufloxacin mesilate were 27.47% and 32.97%, respectively. CONCLUSIONS There is a certain resistance rate of the Shigella to fluoroquinolones and the third generation cephalosporins. More attention should be paid to the surveillance and control of such resistance.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2007年第2期218-220,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金项目(30571654)
关键词
志贺菌属
耐药性
抗菌药物
Shigella
Resistances Antimicrobial agents
