摘要
目的:通过术前应用5-FU和顺铂,同时行食管区的体外照射40Gy,术后行淋巴结微转移检测,了解新辅助放化疗在降低微转移中的作用。方法:120例食管癌患者随机分为单纯手术组、新辅助化疗+手术组,每组60例。新辅助化疗组术前给予5-FU和顺铂,3周为一周期,同时行食管区的体外照射40Gy,完成两周期后在全麻下行左开胸食管部分切除食管胃颈部吻合术,并清扫区域淋巴结。HE染色"阴性淋巴结"组,免疫组化染色。结果:新辅助放化疗组CK(AE1/AE3)单克隆抗体阳性反应淋巴结数明显少于单纯手术组,有显著性差异。结论:新辅助放化疗方案,可以有效控制微转移。
Objective：To evaluate the value of neo - adjuvant radiochemotherapy in the prevention of micrometas- tasis in esophageal squamous cell carcinoma. Methods：All 120 cases of esophageal squamous cell carcinoma were randomly divided in two groups：surgery group and neo - adjuvant radiochemotherapy plus surgery group. The second group：cisplatin,fluorouracil and 40Gy radiotherapy was used before operation. A total of 326 lymph nodes were exam- ined immunohistochemically. Results：AE1/AE3 -positive lymph node metastases were found lesser in neo - adjuvant radiochemotherapy group than in surgery group. Conclusion ： Neo - adjuvant radiochemotherapy is effective in the pre- vention of micrometastasis in esophageal squamous ceil carcinoma.
出处
《现代肿瘤医学》
CAS
2013年第1期94-96,共3页
Journal of Modern Oncology
关键词
新辅助放化疗
食管鳞癌
微转移
neo - adjuvant radiochemotherapy
esophageal squamous cell carcinoma
micrometastasis
