摘要
目的 综述近阶段皮肤组织工程研究领域中的进展。方法 广泛查阅国内外近期有关皮肤组织工程研究的文献 ,着重阐述表皮替代物 ,真皮替代物 ,培养的表皮真皮复合皮片的研究进展和重要问题。结果 多数学者认为理想的皮肤替代物应及时重建已丧失的表皮和真皮结构。目前的研究主要集中在如何尽早移植表皮细胞 ,并保持移植后细胞的活性和功能 ;以及研制能更有效地促进细胞功能 ,诱导创床血管长入 ,移植后可降解 ,无毒性 ,无病原携带风险的细胞外基质。结论 尽早移植表皮细胞 ,缩短创面愈合时间 。
Objective To review the recent progresses on tissue engineering of skin. Methods Recent original articles about tissue engineering of skin were extensively reviewed, which focused on the progresses and major problems concerning the epidermal substitutes, dermal substitutes, cultured dermal epidermal composite skin graft. Results Most investigators had come to conclusion that the optimal skin substitute should provide for immediate reconstruction of both the lost epidermis and dermis. The research was mainly focused on how to transplant epidermal cells immediately, preserve their activity and function, and develop the extracellular matrix which could effectively accelerate the function of transplanted cells, induce vascular growth from the wound bed, could be biodegradable, no toxicity and no danger of carrying pathogen. Conclusion The major research trends of tissue engineering of skin should be focused on the study of immediate transplantation of epidermal cells, accelerate wound healing and developing extracellular matrix of dermis.
出处
《中国修复重建外科杂志》
CAS
CSCD
2000年第4期241-244,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家教委回国人员科研基金资助项目(1999)
关键词
皮肤
组织工程
表皮细胞
皮纤维细胞
细胞外基质
Skin Tissue engineering Epidermal cells Fibroblasts Extracellular matrix
