摘要
目的观察临床使用的四类吸入性麻醉药对肺泡表面张力的影响。方法 ５０只家兔随机分成五组（每组 １０只），一组作为正常对照组（ Ｃ组），另四组分别吸入 ５５％－ ６０％氧化亚氮（ Ｎ组）、４．５％－５％乙醚（Ｅ组）、０．８％－１．０％氟烷（Ｆ组）和０．８％－１．０％异氟醚（Ｉ组），４ ｈ后，用Ｗｉｌｈｅｍｌｙ平衡仪测定其肺泡灌洗液的表面张力。结果与对照组相比，Ｅ、Ｆ、Ｉ三组肺泡灌洗液表面张力明显升高，稳定指数（Ｓ）显著下降（ Ｐ＜ ０． ０１）， Ｎ组无显著性变化（ Ｐ＞ ０． ０５）。结论吸入脂溶性全身麻醉药可使表面张力升高，稳定指数下降。
Objective To observe the effects of four kinds of inhalational anesthetic agents on alveolar surface tension.Methods Fifty rabbits were randomly allocated to inhaling no drug (control group, n = 10), 55 % -60% nitrous oxide (group N, n = 10), 4. 5 % -5 % diethyl ether (group E, n = 10), 0.8%-1.0% halothane (group F, n = 10) or 0.8%-1.0% isoflurane (group I, n = 10) in 4 h, respectirely.Their surface tensions of alveolar lavages were measured by Willbelmy's balancer. Results Compared with those in control group, the surface tensions rose markedly and stability indexes (S ) decreased significantly in group E, group F and group I (P < 0. 01 ), the changes above mentioned were not significant in N group (P > 0. 05 ). Conclusions Inhalation of liposoluble anesthetic agents can increase alveolar surface tension, and decrease the stability index.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第7期420-422,共3页
Chinese Journal of Anesthesiology
关键词
麻醉药
吸入性
肺泡表面张力
Anesthetics
inhalational
Alveolar surface tension
