摘要
综述顶复门原虫(弓形虫、隐孢子虫、疟原虫)诱导宿主microRNAs变化的最新研究进展,以期为寄生虫相关研究提供参考。查阅有关顶复门原虫诱导宿主microRNAs变化的研究资料,分析和总结顶复门原虫引起宿主体内环境变化、改变宿主microRNAs的表达和前两者之间的的关系。顶复门原虫诱导宿主microRNAs的改变可能由以下几个方面引起:宿主自身的免疫应答反应,顶复门原虫通过分泌自己的microRNAs或蛋白质来改变宿主的microRNAs。总之,microRNAs在动物和植物的天然免疫反应中起重要作用,顶复门原虫能干扰宿主microRNAs的表达,从而改变宿主体内环境。
The microRNAs（miRNAs） are a class of single-stranded,non-coding,endogenous small RNAs which are 18-25 nucleotides（nt） in length.They regulate gene expression at the post-transcriptional level by completely or partially pairing with target mRNAs and play a significant role in coordinating the development of parasite and innate immunity in animals and plants.Recent studies have shown that apicomplexan parasites are able to interfere with the expression of host miRNAs,then change host cellular environment.The present paper reviews the latest research advances in expression changes of host miRNAs after infection with apicomplexan parasites such as Toxoplasma gondii,Cryptosporidium parvum and Plasmodium spp.Such changes of infected host might be caused by several reasons.For instance,one reason might be that host cell response and defense（such as inflammatory response） fight against parasites.Some studies have shown that C.parvum could induce cytokine-inducible Src homology 2（CIS） protein expression and coordinate the expression of cytokine signaling（SOCS） protein in host biliary epithelial cells,both of these two proteins play important roles in reactions of host in response to infections of foreign pathogens.Other reasons may include that miRNAs and/or proteins secreted by apicomplexan parasites hijack the host cell miRNAs defense way.After invading into hosts,a few proteins secreted by parasites have been tested that they can change the environment of host cells,such as ROP16,ROP18,GRA15 and UIS3.Arabidopsis miR-393 acts on counteracting the infection of Pseudomonas syringae,and in turn,P.syringae secrets proteins to subvert the small RNA-directed immunity of their host.According to the interaction between Arabidopsis and P.syringae,it is not difficult to presume that there also has some similar relationships between microRNAs and proteins of hosts and apicomplexan parasites.In summary,the host cellular environment will be reshaped by a new means as apicomplexan parasites change host miRNAs expression.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2012年第12期1233-1237,共5页
Chinese Journal of Zoonoses
基金
国家自然科学基金项目(31172316、31101812)
农业科研杰出人才项目
中央级公益性科研院所基本科研业务费专项项目(2012ZL081)
中国农业科学院科技经费项目
家畜疫病病原生物学国家重点实验室开放基金项目(SKLVEB2011KFKT004)资助~~
