摘要
应用间接免疫荧光法和放射免疫法分别检测了 34例鼻咽癌患者外周血中淋巴细胞的数量和血浆前列环素(PGI2 )及血栓素 (TXA2 )的含量 ,并与正常对照组对比研究。结果显示 :鼻咽癌患者外周血中 CD4细胞减少 (P<0 .0 1) ,而 CD8细胞则明显升高 (P<0 .0 5 )。同时鼻咽癌患者血浆中 PGI2 和 TXA2 的稳定代谢产物 6 - keto- PGF1α及 TXB2分别比对照组升高 ,以 TXB2 升高更明显 (P<0 .0 5 )。提示鼻咽癌患者体内前列腺素类物质 PGI2 和 TXA2 与鼻咽癌患者机体细胞免疫功能有关 。
Immunohistochemistry technique and radioimmunoassay were used to measure peripheral blood lymphocytes and determine plasma concentrations of 6 keto PGF1 alpha,thromboxane B 2(TXB 2) respectively in 34 patients with nasopharyngeal carcinoma. The results showed that CD 4 cells were decreased ( P <0 01) and CD 8 cells increased ( P <0 05) in peripheral blood in the patients with nasopharyngeal carcinoma as compared with those in the control group respectively. Simultaneously, the plasma concentrations of 6 keto PGF1 alpha and TXB 2 were higher in the patients with nasopharyngeal carcinoma than in the controls ( P <0 05). It was suggested that thromboxane A 2(TXA 2)/prostacyclin (PGI 2) might be related with the cellular immunity of nasopharyngeal carcinoma. TXA 2/PGI 2 as a possible suppressive agents in cellular immunity of nasopharyngeal carcinoma was discussed.
出处
《同济医科大学学报》
CSCD
2000年第3期262-263,267,共3页
Acta Universitatis Medicinae Tongji
关键词
鼻咽癌
前列环素
血栓素
细胞免疫
nasopharyngeal neoplasms
cellular immunity
prostagcyclin
thromboxane
