摘要
作者对58例正常人和92例恶性肿瘤病人测定了血浆中的6—Keto—PGF_(1α)和TXB_2浓度。结果表明恶性肿瘤病人血浆的6—Keto-PGF_(1α)和TXB_2含量显著高于正常人对照组,增高的程度分别为正常值的2.69倍和2.16倍。说明癌瘤组织合成并释放PGI和TXA_2显著增加。 结果还表明前列腺素与癌瘤大小、转移与否以及病理分型之间未显示相关关系。
The level of 6-Keto-PGF1αand thromboxane B 2 (TXB 2) in plasma was determined with radioimmunoassay in 58 normal subjects and 92 patients with various cancers (including lung, hepatic, gastric, esophageal and pancreatic carcinoma) The resnlts showed that 6-keto-PGF1α in plasma was 10.21 ±2.75pg/ml, and TXB 2 146.031 37.31pg/ml in normal individuals the ratio of 6-Keto-PGF1α to TXB 2 was 0.07;while in Cancer patients 6-Keto-PGF1α was 27.5±16.9pg/ml and TXB 2 315.4±173.4pg/ml, the ratio of 6-Keto-PGF1αto TXB 2 was 0.08. The values of 6-Keto-PGF1α and TXB 2 in plasma of cancer patients were 2.69 folds and 2.16 folds higher than that of the two groups.respectiv-ely. The difference between the two groups was statistically significant (p<0.01). It indicates that, the synthesis and release of PGI2 and TXA2 of Cancer tissues increases greatly as compared to the normals.The study also revealed that the size of tumor, metastssis and histological classification had no obvious relation to PGS.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1993年第1期11-13,共3页
Chinese Journal of Cancer
关键词
前列腺素
前列环素
血栓素
肿瘤
Prostaglandin Prostacyclin Thromboxane Arachidonic acid
